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A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.
Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL. Sebastian S, et al. Among authors: conlan jw. Infect Immun. 2007 May;75(5):2591-602. doi: 10.1128/IAI.01789-06. Epub 2007 Feb 12. Infect Immun. 2007. PMID: 17296751 Free PMC article.
Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization.
Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A. Conlan JW, et al. Vaccine. 2010 Feb 17;28(7):1824-31. doi: 10.1016/j.vaccine.2009.12.001. Epub 2009 Dec 16. Vaccine. 2010. PMID: 20018266 Free PMC article.
81 results