Taylor MD - Search Results

1

New inhibitors of human renin that contain novel replacements at the P2 site.

Doherty AM, Kaltenbronn JS, Hudspeth JP, Repine JT, Roark WH, Sircar I, Tinney FJ, Connolly CJ, Hodges JC, Taylor MD, et al. Doherty AM, et al. Among authors: taylor md. J Med Chem. 1991 Apr;34(4):1258-71. doi: 10.1021/jm00108a004. J Med Chem. 1991. PMID: 1901910

2

Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.

Repine JT, Kaltenbronn JS, Doherty AM, Hamby JM, Himmelsbach RJ, Kornberg BE, Taylor MD, Lunney EA, Humblet C, Rapundalo ST, et al. Repine JT, et al. Among authors: taylor md. J Med Chem. 1992 Mar 20;35(6):1032-42. doi: 10.1021/jm00084a008. J Med Chem. 1992. PMID: 1552498

3

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: taylor md, taylor dg jr. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

4

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.

Doherty AM, Sircar I, Kornberg BE, Quin J 3rd, Winters RT, Kaltenbronn JS, Taylor MD, Batley BL, Rapundalo SR, Ryan MJ, et al. Doherty AM, et al. Among authors: taylor md. J Med Chem. 1992 Jan;35(1):2-14. doi: 10.1021/jm00079a001. J Med Chem. 1992. PMID: 1732531

5

Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3- pyridine-carboxylate and analogues. Synthesis and structure-activity relationships.

Sircar I, Gregor EK, Anderson KR, Haleen SJ, Shih YH, Weishaar RE, Steffen RP, Pugsley TA, Taylor MD. Sircar I, et al. Among authors: taylor md. J Med Chem. 1991 Jul;34(7):2248-60. doi: 10.1021/jm00111a047. J Med Chem. 1991. PMID: 2066997

6

Evaluation of physicochemical parameters important to the oral bioavailability of peptide-like compounds: implications for the synthesis of renin inhibitors.

Hamilton HW, Steinbaugh BA, Stewart BH, Chan OH, Schmid HL, Schroeder R, Ryan MJ, Keiser J, Taylor MD, Blankley CJ, et al. Hamilton HW, et al. Among authors: taylor md. J Med Chem. 1995 Apr 28;38(9):1446-55. doi: 10.1021/jm00009a005. J Med Chem. 1995. PMID: 7739003

7

Structure-activity studies of the C-terminal region of the endothelins and the sarafotoxins.

Doherty AM, Cody WL, Leitz NL, DePue PL, Taylor MD, Rapundalo ST, Hingorani GP, Major TC, Panek RL, Taylor DG. Doherty AM, et al. Among authors: taylor dg, taylor md. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S59-61. doi: 10.1097/00005344-199100177-00016. J Cardiovasc Pharmacol. 1991. PMID: 1725433

8

2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers.

Taylor MD, Badger EW, Steffen RP, Haleen SJ, Pugsley TA, Shih YH, Weishaar RE. Taylor MD, et al. J Med Chem. 1988 Aug;31(8):1659-64. doi: 10.1021/jm00403a030. J Med Chem. 1988. PMID: 2840504

9

PD 122860: a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties.

Haleen SJ, Steffen RP, Sircar I, Major TC, Taylor MD, Pugsley TA, Weishaar RE. Haleen SJ, et al. Among authors: taylor md. J Pharmacol Exp Ther. 1989 Jul;250(1):22-30. J Pharmacol Exp Ther. 1989. PMID: 2473188

10

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.

Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. Rao CM, et al. Among authors: taylor md. J Med Chem. 1993 Sep 3;36(18):2614-20. doi: 10.1021/jm00070a004. J Med Chem. 1993. PMID: 8410973

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