Doherty AM - Search Results

1

New inhibitors of human renin that contain novel replacements at the P2 site.

Doherty AM, Kaltenbronn JS, Hudspeth JP, Repine JT, Roark WH, Sircar I, Tinney FJ, Connolly CJ, Hodges JC, Taylor MD, et al. Doherty AM, et al. J Med Chem. 1991 Apr;34(4):1258-71. doi: 10.1021/jm00108a004. J Med Chem. 1991. PMID: 1901910

2

Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.

Repine JT, Kaltenbronn JS, Doherty AM, Hamby JM, Himmelsbach RJ, Kornberg BE, Taylor MD, Lunney EA, Humblet C, Rapundalo ST, et al. Repine JT, et al. Among authors: doherty am. J Med Chem. 1992 Mar 20;35(6):1032-42. doi: 10.1021/jm00084a008. J Med Chem. 1992. PMID: 1552498

3

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: doherty am. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

4

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.

Doherty AM, Sircar I, Kornberg BE, Quin J 3rd, Winters RT, Kaltenbronn JS, Taylor MD, Batley BL, Rapundalo SR, Ryan MJ, et al. Doherty AM, et al. J Med Chem. 1992 Jan;35(1):2-14. doi: 10.1021/jm00079a001. J Med Chem. 1992. PMID: 1732531

5

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: doherty am. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

6

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

Leonard DM, Shuler KR, Poulter CJ, Eaton SR, Sawyer TK, Hodges JC, Su TZ, Scholten JD, Gowan RC, Sebolt-Leopold JS, Doherty AM. Leonard DM, et al. Among authors: doherty am. J Med Chem. 1997 Jan 17;40(2):192-200. doi: 10.1021/jm960602m. J Med Chem. 1997. PMID: 9003517

7

Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.

Hamby JM, Connolly CJ, Schroeder MC, Winters RT, Showalter HD, Panek RL, Major TC, Olsewski B, Ryan MJ, Dahring T, Lu GH, Keiser J, Amar A, Shen C, Kraker AJ, Slintak V, Nelson JM, Fry DW, Bradford L, Hallak H, Doherty AM. Hamby JM, et al. Among authors: doherty am. J Med Chem. 1997 Jul 18;40(15):2296-303. doi: 10.1021/jm970367n. J Med Chem. 1997. PMID: 9240345

8

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM. Patt WC, et al. Among authors: doherty am. J Med Chem. 1997 Mar 28;40(7):1063-74. doi: 10.1021/jm9606507. J Med Chem. 1997. PMID: 9089328

9

C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice.

McNamara DJ, Dobrusin E, Leonard DM, Shuler KR, Kaltenbronn JS, Quin J 3rd, Bur S, Thomas CE, Doherty AM, Scholten JD, Zimmerman KK, Gibbs BS, Gowan RC, Latash MP, Leopold WR, Przybranowski SA, Sebolt-Leopold JS. McNamara DJ, et al. Among authors: doherty am. J Med Chem. 1997 Oct 10;40(21):3319-22. doi: 10.1021/jm970470c. J Med Chem. 1997. PMID: 9341905 No abstract available.

10

Butenolide endothelin antagonists with improved aqueous solubility.

Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, Doherty AM, Welch KM, Bryant JW, Flynn MA, Walker DM, Schroeder RL, Haleen SJ, Keiser JA. Patt WC, et al. Among authors: doherty am. J Med Chem. 1999 Jun 17;42(12):2162-8. doi: 10.1021/jm980504w. J Med Chem. 1999. PMID: 10377221

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