Kern JA - Search Results

1

Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.

Tang Z, Jiang S, Du R, Petri ET, El-Telbany A, Chan PS, Kijima T, Dietrich S, Matsui K, Kobayashi M, Sasada S, Okamoto N, Suzuki H, Kawahara K, Iwasaki T, Nakagawa K, Kawase I, Christensen JG, Hirashima T, Halmos B, Salgia R, Boggon TJ, Kern JA, Ma PC. Tang Z, et al. Among authors: kern ja. Oncogene. 2009 Jan 29;28(4):518-33. doi: 10.1038/onc.2008.411. Epub 2008 Nov 17. Oncogene. 2009. PMID: 19015641 Free PMC article.

2

Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies.

Yu Z, Boggon TJ, Kobayashi S, Jin C, Ma PC, Dowlati A, Kern JA, Tenen DG, Halmos B. Yu Z, et al. Among authors: kern ja. Cancer Res. 2007 Nov 1;67(21):10417-27. doi: 10.1158/0008-5472.CAN-07-1248. Cancer Res. 2007. PMID: 17974985

3

Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer.

Tang Z, Du R, Jiang S, Wu C, Barkauskas DS, Richey J, Molter J, Lam M, Flask C, Gerson S, Dowlati A, Liu L, Lee Z, Halmos B, Wang Y, Kern JA, Ma PC. Tang Z, et al. Among authors: kern ja. Br J Cancer. 2008 Sep 16;99(6):911-22. doi: 10.1038/sj.bjc.6604559. Br J Cancer. 2008. PMID: 19238632 Free PMC article.

4

Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer.

Kluge A, Dabir S, Kern J, Nethery D, Halmos B, Ma P, Dowlati A. Kluge A, et al. Int J Cancer. 2009 Oct 1;125(7):1728-34. doi: 10.1002/ijc.24553. Int J Cancer. 2009. PMID: 19569236 Free PMC article.

5

SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2.

Dowlati A, Kluge A, Nethery D, Halmos B, Kern JA. Dowlati A, et al. Among authors: kern ja. Anticancer Drugs. 2008 Jan;19(1):9-16. doi: 10.1097/CAD.0b013e3282f1a908. Anticancer Drugs. 2008. PMID: 18043125

6

Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.

Zhou H, Liu L, Lee K, Qin X, Grasso AW, Kung HJ, Willis JE, Kern J, Wagner T, Gerson SL. Zhou H, et al. Oncogene. 2002 Dec 12;21(57):8732-40. doi: 10.1038/sj.onc.1205984. Oncogene. 2002. PMID: 12483526

7

Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.

Dowlati A, Nethery D, Kern JA. Dowlati A, et al. Among authors: kern ja. Mol Cancer Ther. 2004 Apr;3(4):459-63. Mol Cancer Ther. 2004. PMID: 15078989

8

Activation state EGFR and STAT-3 as prognostic markers in resected non-small cell lung cancer.

Cortas T, Eisenberg R, Fu P, Kern J, Patrick L, Dowlati A. Cortas T, et al. Lung Cancer. 2007 Mar;55(3):349-55. doi: 10.1016/j.lungcan.2006.11.003. Epub 2006 Dec 8. Lung Cancer. 2007. PMID: 17161498

9

Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.

Liu J, Nethery D, Kern JA. Liu J, et al. Among authors: kern ja. Exp Lung Res. 2004 Sep;30(6):465-78. doi: 10.1080/01902140490476454. Exp Lung Res. 2004. PMID: 15524405 Free article.

10

Bleomycin-induced pulmonary fibrosis is attenuated by a monoclonal antibody targeting HER2.

Faress JA, Nethery DE, Kern EF, Eisenberg R, Jacono FJ, Allen CL, Kern JA. Faress JA, et al. Among authors: kern ef, kern ja. J Appl Physiol (1985). 2007 Dec;103(6):2077-83. doi: 10.1152/japplphysiol.00239.2007. Epub 2007 Oct 4. J Appl Physiol (1985). 2007. PMID: 17916677 Free article.

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