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Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics.
Stiff C, Graber DR, Thorarensen A, Wakefield BD, Marotti KR, Melchior EP, Sweeney MT, Han F, Rohrer DC, Zurenko GE, Romero DL. Stiff C, et al. Among authors: thorarensen a. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6293-7. doi: 10.1016/j.bmcl.2007.08.041. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2008. PMID: 18951783
Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition.
Thorarensen A, Deibel MR Jr, Rohrer DC, Vosters AF, Yem AW, Marshall VD, Lynn JC, Bohanon MJ, Tomich PK, Zurenko GE, Sweeney MT, Jensen RM, Nielsen JW, Seest EP, Dolak LA. Thorarensen A, et al. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1355-8. doi: 10.1016/s0960-894x(01)00242-6. Bioorg Med Chem Lett. 2001. PMID: 11378353
3-Arylpiperidines as potentiators of existing antibacterial agents.
Thorarensen A, Presley-Bodnar AL, Marotti KR, Boyle TP, Heckaman CL, Bohanon MJ, Tomich PK, Zurenko GE, Sweeney MT, Yagi BH. Thorarensen A, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1903-6. doi: 10.1016/s0960-894x(01)00330-4. Bioorg Med Chem Lett. 2001. PMID: 11459657
Enols as potent antibacterial agents.
Thorarensen A, Zurenko GE, Sweeney MT, Marotti KR, Boyle TP. Thorarensen A, et al. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2931-4. doi: 10.1016/s0960-894x(01)00587-x. Bioorg Med Chem Lett. 2001. PMID: 11677129
2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
Trujillo JI, Kiefer JR, Huang W, Thorarensen A, Xing L, Caspers NL, Day JE, Mathis KJ, Kretzmer KK, Reitz BA, Weinberg RA, Stegeman RA, Wrightstone A, Christine L, Compton R, Li X. Trujillo JI, et al. Among authors: thorarensen a. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11. doi: 10.1016/j.bmcl.2008.11.105. Epub 2008 Dec 6. Bioorg Med Chem Lett. 2009. PMID: 19097791
43 results