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HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs.
Sawyer TK, Staples DJ, Liu L, Tomasselli AG, Hui JO, O'Connell K, Schostarez H, Hester JB, Moon J, Howe WJ, et al. Sawyer TK, et al. Among authors: staples dj. Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):274-81. doi: 10.1111/j.1399-3011.1992.tb00302.x. Int J Pept Protein Res. 1992. PMID: 1478785
Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.
Sawyer TK, Pals DT, Mao B, Staples DJ, de Vaux AE, Maggiora LL, Affholter JA, Kati W, Duchamp D, Hester JB, et al. Sawyer TK, et al. Among authors: staples dj. J Med Chem. 1988 Jan;31(1):18-30. doi: 10.1021/jm00396a006. J Med Chem. 1988. PMID: 3275777
Exploiting the molecular template of angiotensinogen in the discovery and design of peptidyl, pseudopeptidyl and peptidimimetic inhibitors of human renin: a structure-activity perspective.
Sawyer TK, Hester JB, Schostarez HJ, Thaisrivongs S, Bundy GL, Liu L, Bradford VS, De Vaux AE, Staples DJ, Maggiora LL, et al. Sawyer TK, et al. Among authors: staples dj. Adv Exp Med Biol. 1991;306:307-23. doi: 10.1007/978-1-4684-6012-4_37. Adv Exp Med Biol. 1991. PMID: 1812721 Review. No abstract available.
25 results