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An experimental method for the determination of enzyme-competitive inhibitor dissociation constants from displacement curves: application to human renin using fluorescence energy transfer to a synthetic dansylated inhibitor peptide.
Epps DE, Schostarez H, Argoudelis CV, Poorman R, Hinzmann J, Sawyer TK, Mandel F. Epps DE, et al. Among authors: sawyer tk. Anal Biochem. 1989 Aug 15;181(1):172-81. doi: 10.1016/0003-2697(89)90413-2. Anal Biochem. 1989. PMID: 2683862
Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.
Sawyer TK, Pals DT, Mao B, Staples DJ, de Vaux AE, Maggiora LL, Affholter JA, Kati W, Duchamp D, Hester JB, et al. Sawyer TK, et al. J Med Chem. 1988 Jan;31(1):18-30. doi: 10.1021/jm00396a006. J Med Chem. 1988. PMID: 3275777
208 results