Le PT - Search Results

1

Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL.

Rikhof B, van der Graaf WT, Meijer C, Le PT, Meersma GJ, de Jong S, Fletcher JA, Suurmeijer AJ. Rikhof B, et al. Among authors: le pt. Br J Cancer. 2008 Nov 18;99(10):1600-6. doi: 10.1038/sj.bjc.6604736. Epub 2008 Oct 21. Br J Cancer. 2008. PMID: 18941456 Free PMC article.

2

Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.

Meijer A, Kruyt FA, van der Zee AG, Hollema H, Le P, ten Hoor KA, Groothuis GM, Quax WJ, de Vries EG, de Jong S. Meijer A, et al. Br J Cancer. 2013 Nov 12;109(10):2685-95. doi: 10.1038/bjc.2013.636. Epub 2013 Oct 17. Br J Cancer. 2013. PMID: 24136147 Free PMC article.

3

Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5.

van Geelen CM, Pennarun B, Le PT, de Vries EG, de Jong S. van Geelen CM, et al. Among authors: le pt. BMC Cancer. 2011 Jan 27;11:39. doi: 10.1186/1471-2407-11-39. BMC Cancer. 2011. PMID: 21272366 Free PMC article.

4

Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.

Van Geelen CM, Pennarun B, Ek WB, Le PT, Spierings DC, De Vries EG, De Jong S. Van Geelen CM, et al. Among authors: le pt. Int J Oncol. 2010 Oct;37(4):1031-41. doi: 10.3892/ijo_00000755. Int J Oncol. 2010. PMID: 20811726

5

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

Christensen JG, Schreck R, Burrows J, Kuruganti P, Chan E, Le P, Chen J, Wang X, Ruslim L, Blake R, Lipson KE, Ramphal J, Do S, Cui JJ, Cherrington JM, Mendel DB. Christensen JG, et al. Cancer Res. 2003 Nov 1;63(21):7345-55. Cancer Res. 2003. PMID: 14612533

6

Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.

Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S, Blake RA, Howlett AR, Patel N, McMahon G, Lipson KE. Wang X, et al. Mol Cancer Ther. 2003 Nov;2(11):1085-92. Mol Cancer Ther. 2003. PMID: 14617781

7

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.

Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, Howlett AR, Bischoff JR, Lipson KE, Jallal B. Wright JH, et al. Mol Cell Biol. 2003 Mar;23(6):2068-82. doi: 10.1128/MCB.23.6.2068-2082.2003. Mol Cell Biol. 2003. PMID: 12612079 Free PMC article.

8

Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.

Cui JJ, McTigue M, Nambu M, Tran-Dubé M, Pairish M, Shen H, Jia L, Cheng H, Hoffman J, Le P, Jalaie M, Goetz GH, Ryan K, Grodsky N, Deng YL, Parker M, Timofeevski S, Murray BW, Yamazaki S, Aguirre S, Li Q, Zou H, Christensen J. Cui JJ, et al. J Med Chem. 2012 Sep 27;55(18):8091-109. doi: 10.1021/jm300967g. Epub 2012 Sep 10. J Med Chem. 2012. PMID: 22924734

9

A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability.

Patel N, Sun L, Moshinsky D, Chen H, Leahy KM, Le P, Moss KG, Wang X, Rice A, Tam D, Laird AD, Yu X, Zhang Q, Tang C, McMahon G, Howlett A. Patel N, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):838-45. doi: 10.1124/jpet.103.052167. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766257

10

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.

Cheng H, Hoffman JE, Le PT, Pairish M, Kania R, Farrell W, Bagrodia S, Yuan J, Sun S, Zhang E, Xiang C, Dalvie D, Rahavendran SV. Cheng H, et al. Among authors: le pt. Bioorg Med Chem Lett. 2013 May 1;23(9):2787-92. doi: 10.1016/j.bmcl.2013.02.020. Epub 2013 Feb 13. Bioorg Med Chem Lett. 2013. PMID: 23506825

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