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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ. Millar JK, et al. Science. 2005 Nov 18;310(5751):1187-91. doi: 10.1126/science.1112915. Science. 2005. PMID: 16293762
The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ. Wang Q, et al. Among authors: brandon nj. Mol Psychiatry. 2011 Oct;16(10):1006-23. doi: 10.1038/mp.2010.87. Epub 2010 Sep 14. Mol Psychiatry. 2011. PMID: 20838393 Free PMC article.
How has DISC1 enabled drug discovery?
Wang Q, Jaaro-Peled H, Sawa A, Brandon NJ. Wang Q, et al. Mol Cell Neurosci. 2008 Feb;37(2):187-95. doi: 10.1016/j.mcn.2007.10.006. Epub 2007 Oct 23. Mol Cell Neurosci. 2008. PMID: 18055216 Review.
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.
Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS. Yalla K, et al. Among authors: brandon nj. Mol Psychiatry. 2018 May;23(5):1278-1286. doi: 10.1038/mp.2017.138. Epub 2017 Jul 20. Mol Psychiatry. 2018. PMID: 28727686 Free PMC article.
226 results