Tokita S - Search Results

1

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Sato N. Nagase T, et al. Among authors: tokita s. J Med Chem. 2008 Nov 13;51(21):6889-901. doi: 10.1021/jm800569w. Epub 2008 Oct 8. J Med Chem. 2008. PMID: 18841880

2

Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.

Ito S, Yoshimoto R, Miyamoto Y, Mitobe Y, Nakamura T, Ishihara A, MacNeil DJ, Kanatani A, Tokita S. Ito S, et al. Among authors: tokita s. Eur J Pharmacol. 2006 Jan 4;529(1-3):40-6. doi: 10.1016/j.ejphar.2005.10.066. Epub 2005 Nov 28. Eur J Pharmacol. 2006. PMID: 16316645

3

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.

Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, Chen AS, Chen HY, Macneil DJ, Kanatani A, Tokita S. Yoshimoto R, et al. Among authors: tokita s. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13866-71. doi: 10.1073/pnas.0506104103. Epub 2006 Sep 5. Proc Natl Acad Sci U S A. 2006. PMID: 16954192 Free PMC article.

4

Distinctive role of central histamine H3 receptor in various orexigenic pathways.

Yoshimoto R, Kanatani A, Tokita S. Yoshimoto R, et al. Among authors: tokita s. Eur J Pharmacol. 2008 Jan 28;579(1-3):229-32. doi: 10.1016/j.ejphar.2007.11.001. Epub 2007 Nov 13. Eur J Pharmacol. 2008. PMID: 18037404

5

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, Sato N. Nagase T, et al. Among authors: tokita s. J Med Chem. 2008 Aug 14;51(15):4780-9. doi: 10.1021/jm8003834. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598020

6

Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists.

Jitsuoka M, Tsukahara D, Ito S, Tanaka T, Takenaga N, Tokita S, Sato N. Jitsuoka M, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5101-6. doi: 10.1016/j.bmcl.2008.07.125. Epub 2008 Aug 5. Bioorg Med Chem Lett. 2008. PMID: 18768318

7

Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Mizutani T, Nagase T, Ito S, Miyamoto Y, Tanaka T, Takenaga N, Tokita S, Sato N. Mizutani T, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6041-5. doi: 10.1016/j.bmcl.2008.10.034. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18952421

8

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

Ito M, Sakamoto T, Suzuki T, Egashira S, Moriya M, Ishihara A, Iwaasa H, Matsushita H, Nakase K, Wallace MA, Dean D, Sato N, Tokita S, Kanatani A. Ito M, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2009 May 15;19(10):2835-9. doi: 10.1016/j.bmcl.2009.03.102. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19361985

9

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Takahashi T, et al. Among authors: tokita s. J Med Chem. 2009 May 28;52(10):3142-5. doi: 10.1021/jm900391x. J Med Chem. 2009. PMID: 19388647

10

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.

Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T. Suzuki T, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3072-7. doi: 10.1016/j.bmcl.2009.04.016. Epub 2009 Apr 9. Bioorg Med Chem Lett. 2009. PMID: 19403308

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