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Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.
Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ. Gentry DR, et al. Among authors: holmes dj. Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9. doi: 10.1128/AAC.47.6.1784-1789.2003. Antimicrob Agents Chemother. 2003. PMID: 12760849 Free PMC article.
Genomic approaches to antibacterial discovery.
Payne DJ, Gwynn MN, Holmes DJ, Rosenberg M. Payne DJ, et al. Among authors: holmes dj. Methods Mol Biol. 2004;266:231-59. doi: 10.1385/1-59259-763-7:231. Methods Mol Biol. 2004. PMID: 15148422
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR. O'Dwyer K, et al. Among authors: holmes dj. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348524 Free PMC article. Clinical Trial.
Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.
Min S, Ingraham K, Huang J, McCloskey L, Rilling S, Windau A, Pizzollo J, Butler D, Aubart K, Miller LA, Zalacain M, Holmes DJ, O'Dwyer K. Min S, et al. Among authors: holmes dj. Antimicrob Agents Chemother. 2015 Aug;59(8):4644-52. doi: 10.1128/AAC.00484-15. Epub 2015 May 26. Antimicrob Agents Chemother. 2015. PMID: 26014938 Free PMC article.
New benzylidenethiazolidinediones as antibacterial agents.
Heerding DA, Christmann LT, Clark TJ, Holmes DJ, Rittenhouse SF, Takata DT, Venslavsky JW. Heerding DA, et al. Among authors: holmes dj. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3771-3. doi: 10.1016/j.bmcl.2003.07.010. Bioorg Med Chem Lett. 2003. PMID: 14552776
89 results