Akinaga S - Search Results

1

Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors.

Ishida H, Isami S, Matsumura T, Umehara H, Yamashita Y, Kajita J, Fuse E, Kiyoi H, Naoe T, Akinaga S, Shiotsu Y, Arai H. Ishida H, et al. Among authors: akinaga s. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5472-7. doi: 10.1016/j.bmcl.2008.09.031. Epub 2008 Sep 11. Bioorg Med Chem Lett. 2008. PMID: 18835166

2

Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.

Ikuina Y, Amishiro N, Miyata M, Narumi H, Ogawa H, Akiyama T, Shiotsu Y, Akinaga S, Murakata C. Ikuina Y, et al. Among authors: akinaga s. J Med Chem. 2003 Jun 5;46(12):2534-41. doi: 10.1021/jm030110r. J Med Chem. 2003. PMID: 12773056

3

[FLT3 tyrosine kinase inhibitors: current status and future perspectives for their development].

Akinaga S, Shiotsu Y, Kiyoi H, Naoe T. Akinaga S, et al. Nihon Yakurigaku Zasshi. 2008 Oct;132(4):217-20. doi: 10.1254/fpj.132.217. Nihon Yakurigaku Zasshi. 2008. PMID: 18854623 Review. Japanese. No abstract available.

4

Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.

Yamamoto J, Amishiro N, Kato K, Ohta Y, Ino Y, Araki M, Tsujita T, Okamoto S, Takahashi T, Kusaka H, Akinaga S, Yamashita Y, Nakai R, Murakata C. Yamamoto J, et al. Among authors: akinaga s. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3961-3. doi: 10.1016/j.bmcl.2014.06.034. Epub 2014 Jun 20. Bioorg Med Chem Lett. 2014. PMID: 25001485

5

A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations.

Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Shimizu M, Arai H, Ishii K, Akinaga S, Naoe T. Kiyoi H, et al. Among authors: akinaga s. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4575-82. doi: 10.1158/1078-0432.CCR-07-0225. Clin Cancer Res. 2007. PMID: 17671144

6

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.

Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T. Shiotsu Y, et al. Among authors: akinaga s. Blood. 2009 Aug 20;114(8):1607-17. doi: 10.1182/blood-2009-01-199307. Epub 2009 Jun 18. Blood. 2009. PMID: 19541823 Free article.

7

Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities.

Agatsuma T, Ogawa H, Akasaka K, Asai A, Yamashita Y, Mizukami T, Akinaga S, Saitoh Y. Agatsuma T, et al. Among authors: akinaga s. Bioorg Med Chem. 2002 Nov;10(11):3445-54. doi: 10.1016/s0968-0896(02)00260-2. Bioorg Med Chem. 2002. PMID: 12213458

8

Telomerase inhibitors identified by a forward chemical genetics approach using a yeast strain with shortened telomere length.

Nakai R, Ishida H, Asai A, Ogawa H, Yamamoto Y, Kawasaki H, Akinaga S, Mizukami T, Yamashita Y. Nakai R, et al. Among authors: akinaga s. Chem Biol. 2006 Feb;13(2):183-90. doi: 10.1016/j.chembiol.2005.11.010. Chem Biol. 2006. PMID: 16492566

9

A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models.

Ishida H, Nakata T, Suzuki M, Shiotsu Y, Tanaka H, Sato N, Terasaki Y, Takebayashi M, Anazawa H, Murakata C, Li PK, Kuwabara T, Akinaga S. Ishida H, et al. Among authors: akinaga s. Breast Cancer Res Treat. 2007 Dec;106(2):215-27. doi: 10.1007/s10549-007-9495-x. Epub 2007 Feb 1. Breast Cancer Res Treat. 2007. PMID: 17268815

10

Hsp90 inhibitors as anti-cancer agents, from basic discoveries to clinical development.

Soga S, Akinaga S, Shiotsu Y. Soga S, et al. Among authors: akinaga s. Curr Pharm Des. 2013;19(3):366-76. doi: 10.2174/138161213804143617. Curr Pharm Des. 2013. PMID: 22920907 Review.

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