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Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Park MA, Zhang G, Mitchell C, Rahmani M, Hamed H, Hagan MP, Yacoub A, Curiel DT, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: mitchell c. Mol Cancer Ther. 2008 Sep;7(9):2633-48. doi: 10.1158/1535-7163.MCT-08-0400. Mol Cancer Ther. 2008. PMID: 18790746 Free PMC article.
BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P. Martin AP, et al. Among authors: mitchell c. Mol Pharmacol. 2009 Aug;76(2):327-41. doi: 10.1124/mol.109.056309. Epub 2009 May 29. Mol Pharmacol. 2009. PMID: 19483105 Free PMC article.
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P. Yacoub A, et al. Among authors: mitchell c. Cancer Res. 2010 Feb 1;70(3):1120-9. doi: 10.1158/0008-5472.CAN-09-4043. Epub 2010 Jan 26. Cancer Res. 2010. PMID: 20103619 Free PMC article.
4,072 results