Harding A - Search Results

1

Activation of the MAPK module from different spatial locations generates distinct system outputs.

Inder K, Harding A, Plowman SJ, Philips MR, Parton RG, Hancock JF. Inder K, et al. Among authors: harding a. Mol Biol Cell. 2008 Nov;19(11):4776-84. doi: 10.1091/mbc.e08-04-0407. Epub 2008 Sep 10. Mol Biol Cell. 2008. PMID: 18784252 Free PMC article.

2

Using plasma membrane nanoclusters to build better signaling circuits.

Harding AS, Hancock JF. Harding AS, et al. Trends Cell Biol. 2008 Aug;18(8):364-71. doi: 10.1016/j.tcb.2008.05.006. Epub 2008 Jul 10. Trends Cell Biol. 2008. PMID: 18620858 Free PMC article. Review.

3

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction.

Tian T, Harding A, Inder K, Plowman S, Parton RG, Hancock JF. Tian T, et al. Among authors: harding a. Nat Cell Biol. 2007 Aug;9(8):905-14. doi: 10.1038/ncb1615. Epub 2007 Jul 8. Nat Cell Biol. 2007. PMID: 17618274

4

Ras nanoclusters: combining digital and analog signaling.

Harding A, Hancock JF. Harding A, et al. Cell Cycle. 2008 Jan 15;7(2):127-34. doi: 10.4161/cc.7.2.5237. Epub 2007 Oct 26. Cell Cycle. 2008. PMID: 18212529 Free PMC article. Review.

5

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity.

Prior IA, Harding A, Yan J, Sluimer J, Parton RG, Hancock JF. Prior IA, et al. Among authors: harding a. Nat Cell Biol. 2001 Apr;3(4):368-75. doi: 10.1038/35070050. Nat Cell Biol. 2001. PMID: 11283610

6

Subcellular localization determines MAP kinase signal output.

Harding A, Tian T, Westbury E, Frische E, Hancock JF. Harding A, et al. Curr Biol. 2005 May 10;15(9):869-73. doi: 10.1016/j.cub.2005.04.020. Curr Biol. 2005. PMID: 15886107 Free article.

7

Mechanism of mitosis-specific activation of MEK1.

Harding A, Giles N, Burgess A, Hancock JF, Gabrielli BG. Harding A, et al. J Biol Chem. 2003 May 9;278(19):16747-54. doi: 10.1074/jbc.M301015200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12609978 Free article.

8

Identification of residues and domains of Raf important for function in vivo and in vitro.

Harding A, Hsu V, Kornfeld K, Hancock JF. Harding A, et al. J Biol Chem. 2003 Nov 14;278(46):45519-27. doi: 10.1074/jbc.M303106200. Epub 2003 Sep 3. J Biol Chem. 2003. PMID: 12954633 Free article.

9

MAPK pathway activation delays G2/M progression by destabilizing Cdc25B.

Astuti P, Pike T, Widberg C, Payne E, Harding A, Hancock J, Gabrielli B. Astuti P, et al. Among authors: harding a. J Biol Chem. 2009 Dec 4;284(49):33781-8. doi: 10.1074/jbc.M109.027516. Epub 2009 Oct 1. J Biol Chem. 2009. PMID: 19801682 Free PMC article.

10

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains.

Roy S, Luetterforst R, Harding A, Apolloni A, Etheridge M, Stang E, Rolls B, Hancock JF, Parton RG. Roy S, et al. Among authors: harding a. Nat Cell Biol. 1999 Jun;1(2):98-105. doi: 10.1038/10067. Nat Cell Biol. 1999. PMID: 10559881

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