Isaya G - Search Results

1

Assembly of the iron-binding protein frataxin in Saccharomyces cerevisiae responds to dynamic changes in mitochondrial iron influx and stress level.

Gakh O, Smith DY 4th, Isaya G. Gakh O, et al. Among authors: isaya g. J Biol Chem. 2008 Nov 14;283(46):31500-10. doi: 10.1074/jbc.M805415200. Epub 2008 Sep 9. J Biol Chem. 2008. PMID: 18784075 Free PMC article.

2

Physical evidence that yeast frataxin is an iron storage protein.

Gakh O, Adamec J, Gacy AM, Twesten RD, Owen WG, Isaya G. Gakh O, et al. Among authors: isaya g. Biochemistry. 2002 May 28;41(21):6798-804. doi: 10.1021/bi025566+. Biochemistry. 2002. PMID: 12022884

3

The ferroxidase activity of yeast frataxin.

Park S, Gakh O, Mooney SM, Isaya G. Park S, et al. Among authors: isaya g. J Biol Chem. 2002 Oct 11;277(41):38589-95. doi: 10.1074/jbc.M206711200. Epub 2002 Jul 30. J Biol Chem. 2002. PMID: 12149269 Free PMC article.

4

Mitochondrial processing peptidases.

Gakh O, Cavadini P, Isaya G. Gakh O, et al. Among authors: isaya g. Biochim Biophys Acta. 2002 Sep 2;1592(1):63-77. doi: 10.1016/s0167-4889(02)00265-3. Biochim Biophys Acta. 2002. PMID: 12191769 Free article. Review.

5

Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation.

Park S, Gakh O, O'Neill HA, Mangravita A, Nichol H, Ferreira GC, Isaya G. Park S, et al. Among authors: isaya g. J Biol Chem. 2003 Aug 15;278(33):31340-51. doi: 10.1074/jbc.M303158200. Epub 2003 May 5. J Biol Chem. 2003. PMID: 12732649 Free article.

6

Supramolecular assemblies of human frataxin are formed via subunit-subunit interactions mediated by a non-conserved amino-terminal region.

O'Neill HA, Gakh O, Isaya G. O'Neill HA, et al. Among authors: isaya g. J Mol Biol. 2005 Jan 21;345(3):433-9. doi: 10.1016/j.jmb.2004.10.074. J Mol Biol. 2005. PMID: 15581888

7

Assembly of human frataxin is a mechanism for detoxifying redox-active iron.

O'Neill HA, Gakh O, Park S, Cui J, Mooney SM, Sampson M, Ferreira GC, Isaya G. O'Neill HA, et al. Among authors: isaya g. Biochemistry. 2005 Jan 18;44(2):537-45. doi: 10.1021/bi048459j. Biochemistry. 2005. PMID: 15641778

8

Molecular and functional characterization of a human frataxin mutation found in hypertrophic cardiomyopathy.

Van Driest SL, Gakh O, Ommen SR, Isaya G, Ackerman MJ. Van Driest SL, et al. Among authors: isaya g. Mol Genet Metab. 2005 Aug;85(4):280-5. doi: 10.1016/j.ymgme.2005.04.010. Mol Genet Metab. 2005. PMID: 15936968

9

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity.

Gakh O, Park S, Liu G, Macomber L, Imlay JA, Ferreira GC, Isaya G. Gakh O, et al. Among authors: isaya g. Hum Mol Genet. 2006 Feb 1;15(3):467-79. doi: 10.1093/hmg/ddi461. Epub 2005 Dec 21. Hum Mol Genet. 2006. PMID: 16371422

10

Oligomeric yeast frataxin drives assembly of core machinery for mitochondrial iron-sulfur cluster synthesis.

Li H, Gakh O, Smith DY 4th, Isaya G. Li H, et al. Among authors: isaya g. J Biol Chem. 2009 Aug 14;284(33):21971-21980. doi: 10.1074/jbc.M109.011197. Epub 2009 Jun 2. J Biol Chem. 2009. PMID: 19491103 Free PMC article.

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