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Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver.
Leipnitz G, Seminotti B, Fernandes CG, Amaral AU, Beskow AP, da Silva Lde B, Zanatta A, Ribeiro CA, Vargas CR, Wajner M. Leipnitz G, et al. Among authors: beskow ap. Int J Dev Neurosci. 2009 Jun;27(4):351-6. doi: 10.1016/j.ijdevneu.2009.03.001. Epub 2009 Mar 13. Int J Dev Neurosci. 2009. PMID: 19460629