Young PR - Search Results

1

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.

Stoermer MJ, Chappell KJ, Liebscher S, Jensen CM, Gan CH, Gupta PK, Xu WJ, Young PR, Fairlie DP. Stoermer MJ, et al. Among authors: young pr. J Med Chem. 2008 Sep 25;51(18):5714-21. doi: 10.1021/jm800503y. Epub 2008 Aug 26. J Med Chem. 2008. PMID: 18729351

2

Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

Brinkworth RI, Fairlie DP, Leung D, Young PR. Brinkworth RI, et al. Among authors: young pr. J Gen Virol. 1999 May;80 ( Pt 5):1167-1177. doi: 10.1099/0022-1317-80-5-1167. J Gen Virol. 1999. PMID: 10355763

3

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

Leung D, Schroder K, White H, Fang NX, Stoermer MJ, Abbenante G, Martin JL, Young PR, Fairlie DP. Leung D, et al. Among authors: young pr. J Biol Chem. 2001 Dec 7;276(49):45762-71. doi: 10.1074/jbc.M107360200. Epub 2001 Oct 1. J Biol Chem. 2001. PMID: 11581268 Free article.

4

Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography.

Arakaki TL, Fang NX, Fairlie DP, Young PR, Martin JL. Arakaki TL, et al. Among authors: young pr. Protein Expr Purif. 2002 Jul;25(2):241-7. doi: 10.1016/s1046-5928(02)00005-0. Protein Expr Purif. 2002. PMID: 12135556

5

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease.

Nall TA, Chappell KJ, Stoermer MJ, Fang NX, Tyndall JD, Young PR, Fairlie DP. Nall TA, et al. Among authors: young pr. J Biol Chem. 2004 Nov 19;279(47):48535-42. doi: 10.1074/jbc.M406810200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322074 Free article.

6

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

Chappell KJ, Nall TA, Stoermer MJ, Fang NX, Tyndall JD, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. J Biol Chem. 2005 Jan 28;280(4):2896-903. doi: 10.1074/jbc.M409931200. Epub 2004 Oct 19. J Biol Chem. 2005. PMID: 15494419 Free article.

7

Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus.

Shepherd NE, Hoang HN, Desai VS, Letouze E, Young PR, Fairlie DP. Shepherd NE, et al. Among authors: young pr. J Am Chem Soc. 2006 Oct 11;128(40):13284-9. doi: 10.1021/ja064058a. J Am Chem Soc. 2006. PMID: 17017810

8

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. J Biol Chem. 2006 Dec 15;281(50):38448-58. doi: 10.1074/jbc.M607641200. Epub 2006 Oct 19. J Biol Chem. 2006. PMID: 17052977 Free article.

9

Current status of short synthetic peptides as vaccines.

Hans D, Young PR, Fairlie DP. Hans D, et al. Among authors: young pr. Med Chem. 2006 Nov;2(6):627-46. doi: 10.2174/1573406410602060627. Med Chem. 2006. PMID: 17105445 Review.

10

Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. Protein Expr Purif. 2007 May;53(1):87-96. doi: 10.1016/j.pep.2006.10.022. Epub 2006 Nov 7. Protein Expr Purif. 2007. PMID: 17174105

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