Chappell KJ - Search Results

1

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.

Stoermer MJ, Chappell KJ, Liebscher S, Jensen CM, Gan CH, Gupta PK, Xu WJ, Young PR, Fairlie DP. Stoermer MJ, et al. Among authors: chappell kj. J Med Chem. 2008 Sep 25;51(18):5714-21. doi: 10.1021/jm800503y. Epub 2008 Aug 26. J Med Chem. 2008. PMID: 18729351

2

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease.

Nall TA, Chappell KJ, Stoermer MJ, Fang NX, Tyndall JD, Young PR, Fairlie DP. Nall TA, et al. Among authors: chappell kj. J Biol Chem. 2004 Nov 19;279(47):48535-42. doi: 10.1074/jbc.M406810200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322074 Free article.

3

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

Chappell KJ, Nall TA, Stoermer MJ, Fang NX, Tyndall JD, Fairlie DP, Young PR. Chappell KJ, et al. J Biol Chem. 2005 Jan 28;280(4):2896-903. doi: 10.1074/jbc.M409931200. Epub 2004 Oct 19. J Biol Chem. 2005. PMID: 15494419 Free article.

4

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. J Biol Chem. 2006 Dec 15;281(50):38448-58. doi: 10.1074/jbc.M607641200. Epub 2006 Oct 19. J Biol Chem. 2006. PMID: 17052977 Free article.

5

Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Protein Expr Purif. 2007 May;53(1):87-96. doi: 10.1016/j.pep.2006.10.022. Epub 2006 Nov 7. Protein Expr Purif. 2007. PMID: 17174105

6

A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases.

Marcon L, Kozak D, Battersby BJ, Chappell KJ, Fairlie DP, Young P, Trau M. Marcon L, et al. Among authors: chappell kj. Anal Biochem. 2008 May 1;376(1):151-3. doi: 10.1016/j.ab.2008.01.034. Epub 2008 Feb 2. Anal Biochem. 2008. PMID: 18312847

7

Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. J Gen Virol. 2008 Apr;89(Pt 4):1010-1014. doi: 10.1099/vir.0.83447-0. J Gen Virol. 2008. PMID: 18343843

8

West Nile Virus NS2B/NS3 protease as an antiviral target.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Curr Med Chem. 2008;15(27):2771-84. doi: 10.2174/092986708786242804. Curr Med Chem. 2008. PMID: 18991636 Review.

9

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation.

Robin G, Chappell K, Stoermer MJ, Hu SH, Young PR, Fairlie DP, Martin JL. Robin G, et al. J Mol Biol. 2009 Feb 6;385(5):1568-77. doi: 10.1016/j.jmb.2008.11.026. Epub 2008 Nov 25. J Mol Biol. 2009. PMID: 19059417

10

Viral bacterial co-infection of the respiratory tract during early childhood.

Brealey JC, Sly PD, Young PR, Chappell KJ. Brealey JC, et al. Among authors: chappell kj. FEMS Microbiol Lett. 2015 May;362(10):fnv062. doi: 10.1093/femsle/fnv062. Epub 2015 Apr 15. FEMS Microbiol Lett. 2015. PMID: 25877546 Review.

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