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A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB. Liby K, et al. Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123. Cancer Res. 2008. PMID: 18701497 Free PMC article.
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. doi: 10.1073/pnas.0500815102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767573 Free PMC article.
The role of Keap1 in cellular protective responses.
Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.
Electrophilic tuning of the chemoprotective natural product sulforaphane.
Ahn YH, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA. Ahn YH, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9590-5. doi: 10.1073/pnas.1004104107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439747 Free PMC article.
194 results