Connelly S - Search Results

1

Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.

DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL. DeMartino JK, et al. Among authors: connelly s. J Med Chem. 2008 Sep 11;51(17):5441-8. doi: 10.1021/jm800555h. Epub 2008 Aug 8. J Med Chem. 2008. PMID: 18686942 Free PMC article.

2

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Med Chem. 2008 Jan 24;51(2):260-70. doi: 10.1021/jm0708735. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095641

3

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Med Chem. 2008 Oct 23;51(20):6348-58. doi: 10.1021/jm800435s. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811132 Free PMC article.

4

Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. Among authors: connelly s. J Med Chem. 2009 Feb 26;52(4):1115-25. doi: 10.1021/jm801347s. J Med Chem. 2009. PMID: 19191553 Free PMC article.

5

Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.

Connelly S, DeMartino JK, Boger DL, Wilson IA. Connelly S, et al. Biochemistry. 2013 Jul 30;52(30):5133-44. doi: 10.1021/bi4005182. Epub 2013 Jul 19. Biochemistry. 2013. PMID: 23869564 Free PMC article.

6

The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.

Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. Wang W, et al. Among authors: connelly s. J Biol Chem. 2009 Feb 6;284(6):3521-8. doi: 10.1074/jbc.M806707200. Epub 2008 Dec 8. J Biol Chem. 2009. PMID: 19068483 Free PMC article.

7

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.

Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM. Connelly S, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3441-3449. doi: 10.1016/j.bmcl.2017.05.080. Epub 2017 May 26. Bioorg Med Chem Lett. 2017. PMID: 28625364 Free PMC article.

8

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. Choi S, et al. Among authors: connelly s. J Am Chem Soc. 2010 Feb 3;132(4):1359-70. doi: 10.1021/ja908562q. J Am Chem Soc. 2010. PMID: 20043671 Free PMC article.

9

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.

Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Choi S, et al. Among authors: connelly s. Nat Chem Biol. 2010 Feb;6(2):133-9. doi: 10.1038/nchembio.281. Nat Chem Biol. 2010. PMID: 20081815 Free PMC article.

10

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.

Myung N, Connelly S, Kim B, Park SJ, Wilson IA, Kelly JW, Choi S. Myung N, et al. Among authors: connelly s. Chem Commun (Camb). 2013 Oct 14;49(80):9188-9190. doi: 10.1039/c3cc44667k. Epub 2013 Aug 29. Chem Commun (Camb). 2013. PMID: 23989101 Free PMC article.

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