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Niemann-Pick C1 protein regulates platelet membrane-associated calcium ion signaling in thrombo-occlusive diseases in mice.
Manke MC, Roslan A, Walker B, Münzer P, Kollotzek F, Peng B, Mencl S, Coman C, Szepanowski RD, Schulze H, Lieberman AP, Lang F, Gawaz M, Kleinschnitz C, Lukowski R, Ahrends R, Bobe R, Borst O. Manke MC, et al. Among authors: lukowski r. J Thromb Haemost. 2023 Jul;21(7):1957-1966. doi: 10.1016/j.jtha.2023.03.038. Epub 2023 Apr 11. J Thromb Haemost. 2023. PMID: 37054918 Free article.
BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation.
Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, Maier S, Spähn D, Kalina D, Simonsig S, Ehinger R, Groschup B, Knipper M, Plesnila N, Ruth P, Lukowski R, Matt L. Pham T, et al. Among authors: lukowski r. Cell Mol Life Sci. 2023 Nov 21;80(12):369. doi: 10.1007/s00018-023-05016-y. Cell Mol Life Sci. 2023. PMID: 37989805 Free PMC article.
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Balzulat A, Zhu WF, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, Dubiel M, Frank A, Menge A, Hebchen M, Metzner K, Lu R, Lukowski R, Ruth P, Knapp S, Müller S, Steinhilber D, Hänelt I, Stark H, Proschak E, Schmidtko A. Balzulat A, et al. Among authors: lukowski r. Adv Sci (Weinh). 2024 Apr;11(15):e2307237. doi: 10.1002/advs.202307237. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350720 Free PMC article.
mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming.
Bischof H, Maier S, Koprowski P, Kulawiak B, Burgstaller S, Jasińska J, Serafimov K, Zochowska M, Gross D, Schroth W, Matt L, Juarez Lopez DA, Zhang Y, Bonzheim I, Büttner FA, Fend F, Schwab M, Birkenfeld AL, Malli R, Lämmerhofer M, Bednarczyk P, Szewczyk A, Lukowski R. Bischof H, et al. Among authors: lukowski r. Elife. 2024 May 29;12:RP92511. doi: 10.7554/eLife.92511. Elife. 2024. PMID: 38808578 Free PMC article.
Slack K+ channels confer protection against myocardial ischemia/reperfusion injury.
Roslan A, Paulus K, Yang J, Matt L, Bischof H, Längst N, Schanz S, Luczak A, Cruz Santos M, Burgstaller S, Skrabak D, Bork NI, Malli R, Schmidtko A, Gawaz M, Nikolaev VO, Ruth P, Ehinger R, Lukowski R. Roslan A, et al. Among authors: lukowski r. Cardiovasc Res. 2024 Aug 5:cvae155. doi: 10.1093/cvr/cvae155. Online ahead of print. Cardiovasc Res. 2024. PMID: 39102831
Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo.
Bachmann M, Rossa A, Varanita T, Fioretti B, Biasutto L, Milenkovic S, Checchetto V, Peruzzo R, Ahmad SA, Patel SH, Lukowski R, Edwards MJ, Ceccarelli M, Gulbins E, Zoratti M, Mattarei A, Szabo I. Bachmann M, et al. Among authors: lukowski r. Cell Death Dis. 2022 Dec 20;13(12):1055. doi: 10.1038/s41419-022-05463-8. Cell Death Dis. 2022. PMID: 36539400 Free PMC article.
Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling.
Calis D, Hess M, Marchetta P, Singer W, Modro J, Nelissen E, Prickaerts J, Sandner P, Lukowski R, Ruth P, Knipper M, Rüttiger L. Calis D, et al. Among authors: lukowski r. Front Mol Neurosci. 2023 Feb 17;16:1017761. doi: 10.3389/fnmol.2023.1017761. eCollection 2023. Front Mol Neurosci. 2023. PMID: 36873102 Free PMC article.
92 results