Hobbie SN - Search Results

1

Conservation of bacterial protein synthesis machinery: initiation and elongation in Mycobacterium smegmatis.

Bruell CM, Eichholz C, Kubarenko A, Post V, Katunin VI, Hobbie SN, Rodnina MV, Böttger EC. Bruell CM, et al. Among authors: hobbie sn. Biochemistry. 2008 Aug 26;47(34):8828-39. doi: 10.1021/bi800527k. Epub 2008 Aug 2. Biochemistry. 2008. PMID: 18672904

2

The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures.

Pfister P, Hobbie S, Vicens Q, Böttger EC, Westhof E. Pfister P, et al. Chembiochem. 2003 Oct 6;4(10):1078-88. doi: 10.1002/cbic.200300657. Chembiochem. 2003. PMID: 14523926

3

Mutagenesis of 16S rRNA C1409-G1491 base-pair differentiates between 6'OH and 6'NH3+ aminoglycosides.

Pfister P, Hobbie S, Brüll C, Corti N, Vasella A, Westhof E, Böttger EC. Pfister P, et al. J Mol Biol. 2005 Feb 18;346(2):467-75. doi: 10.1016/j.jmb.2004.11.073. Epub 2004 Dec 21. J Mol Biol. 2005. PMID: 15670597

4

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

Pfister P, Corti N, Hobbie S, Bruell C, Zarivach R, Yonath A, Böttger EC. Pfister P, et al. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5180-5. doi: 10.1073/pnas.0501598102. Epub 2005 Mar 28. Proc Natl Acad Sci U S A. 2005. PMID: 15795375 Free PMC article.

5

Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction.

Hobbie SN, Pfister P, Brüll C, Westhof E, Böttger EC. Hobbie SN, et al. Antimicrob Agents Chemother. 2005 Dec;49(12):5112-8. doi: 10.1128/AAC.49.12.5112-5118.2005. Antimicrob Agents Chemother. 2005. PMID: 16304180 Free PMC article.

6

Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.

Hobbie SN, Pfister P, Bruell C, Sander P, François B, Westhof E, Böttger EC. Hobbie SN, et al. Antimicrob Agents Chemother. 2006 Apr;50(4):1489-96. doi: 10.1128/AAC.50.4.1489-1496.2006. Antimicrob Agents Chemother. 2006. PMID: 16569869 Free PMC article.

7

A genetic model to investigate drug-target interactions at the ribosomal decoding site.

Hobbie SN, Bruell C, Kalapala S, Akshay S, Schmidt S, Pfister P, Böttger EC. Hobbie SN, et al. Biochimie. 2006 Aug;88(8):1033-43. doi: 10.1016/j.biochi.2006.04.008. Epub 2006 Apr 27. Biochimie. 2006. PMID: 16690195 Review.

8

Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria.

Hobbie SN, Kalapala SK, Akshay S, Bruell C, Schmidt S, Dabow S, Vasella A, Sander P, Böttger EC. Hobbie SN, et al. Nucleic Acids Res. 2007;35(18):6086-93. doi: 10.1093/nar/gkm658. Epub 2007 Aug 30. Nucleic Acids Res. 2007. PMID: 17766247 Free PMC article.

9

Mitochondrial deafness alleles confer misreading of the genetic code.

Hobbie SN, Bruell CM, Akshay S, Kalapala SK, Shcherbakov D, Böttger EC. Hobbie SN, et al. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3244-9. doi: 10.1073/pnas.0707265105. Epub 2008 Feb 28. Proc Natl Acad Sci U S A. 2008. PMID: 18308926 Free PMC article.

10

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.

Hobbie SN, Akshay S, Kalapala SK, Bruell CM, Shcherbakov D, Böttger EC. Hobbie SN, et al. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20888-93. doi: 10.1073/pnas.0811258106. Epub 2008 Dec 22. Proc Natl Acad Sci U S A. 2008. PMID: 19104050 Free PMC article.

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