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178,238 results

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Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.
Hur W, Velentza A, Kim S, Flatauer L, Jiang X, Valente D, Mason DE, Suzuki M, Larson B, Zhang J, Zagorska A, Didonato M, Nagle A, Warmuth M, Balk SP, Peters EC, Gray NS. Hur W, et al. Among authors: zhang j. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5916-9. doi: 10.1016/j.bmcl.2008.07.062. Epub 2008 Jul 18. Bioorg Med Chem Lett. 2008. PMID: 18667312 Free PMC article.
Broad spectrum alkynyl inhibitors of T315I Bcr-Abl.
Deng X, Lim SM, Zhang J, Gray NS. Deng X, et al. Among authors: zhang j. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4196-200. doi: 10.1016/j.bmcl.2010.05.043. Epub 2010 May 19. Bioorg Med Chem Lett. 2010. PMID: 20541934 Free PMC article.
In situ kinase profiling reveals functionally relevant properties of native kinases.
Patricelli MP, Nomanbhoy TK, Wu J, Brown H, Zhou D, Zhang J, Jagannathan S, Aban A, Okerberg E, Herring C, Nordin B, Weissig H, Yang Q, Lee JD, Gray NS, Kozarich JW. Patricelli MP, et al. Among authors: zhang j. Chem Biol. 2011 Jun 24;18(6):699-710. doi: 10.1016/j.chembiol.2011.04.011. Chem Biol. 2011. PMID: 21700206 Free PMC article.
A structure-guided approach to creating covalent FGFR inhibitors.
Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS. Zhou W, et al. Among authors: zhang j. Chem Biol. 2010 Mar 26;17(3):285-95. doi: 10.1016/j.chembiol.2010.02.007. Chem Biol. 2010. PMID: 20338520 Free PMC article.
Expanding the diversity of allosteric bcr-abl inhibitors.
Deng X, Okram B, Ding Q, Zhang J, Choi Y, Adrián FJ, Wojciechowski A, Zhang G, Che J, Bursulaya B, Cowan-Jacob SW, Rummel G, Sim T, Gray NS. Deng X, et al. Among authors: zhang g, zhang j. J Med Chem. 2010 Oct 14;53(19):6934-46. doi: 10.1021/jm100555f. J Med Chem. 2010. PMID: 20828158 Free PMC article.
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS. Liu Q, et al. Among authors: zhang j. J Med Chem. 2010 Oct 14;53(19):7146-55. doi: 10.1021/jm101144f. J Med Chem. 2010. PMID: 20860370 Free PMC article.
Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.
Hellwig S, Miduturu CV, Kanda S, Zhang J, Filippakopoulos P, Salah E, Deng X, Choi HG, Zhou W, Hur W, Knapp S, Gray NS, Smithgall TE. Hellwig S, et al. Among authors: zhang j. Chem Biol. 2012 Apr 20;19(4):529-40. doi: 10.1016/j.chembiol.2012.01.020. Chem Biol. 2012. PMID: 22520759 Free PMC article.
Development of 'DFG-out' inhibitors of gatekeeper mutant kinases.
Choi HG, Zhang J, Weisberg E, Griffin JD, Sim T, Gray NS. Choi HG, et al. Among authors: zhang j. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5297-302. doi: 10.1016/j.bmcl.2012.06.036. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22819762 Free PMC article.
178,238 results
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