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Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.
Benton CR, Nickerson JG, Lally J, Han XX, Holloway GP, Glatz JF, Luiken JJ, Graham TE, Heikkila JJ, Bonen A. Benton CR, et al. Among authors: bonen a. J Biol Chem. 2008 Feb 15;283(7):4228-40. doi: 10.1074/jbc.M704332200. Epub 2007 Dec 12. J Biol Chem. 2008. PMID: 18079123 Free article.
Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats.
Benton CR, Holloway GP, Han XX, Yoshida Y, Snook LA, Lally J, Glatz JF, Luiken JJ, Chabowski A, Bonen A. Benton CR, et al. Among authors: bonen a. Diabetologia. 2010 Sep;53(9):2008-19. doi: 10.1007/s00125-010-1773-1. Epub 2010 May 20. Diabetologia. 2010. PMID: 20490453
299 results