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2,149 results

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Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.
Imanishi M, Nakajima Y, Tomishima Y, Hamashima H, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K. Imanishi M, et al. Among authors: sakurai m. J Med Chem. 2008 Aug 14;51(15):4804-22. doi: 10.1021/jm800222k. Epub 2008 Jul 24. J Med Chem. 2008. PMID: 18651730
Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.
Imanishi M, Tomishima Y, Itou S, Hamashima H, Nakajima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K. Imanishi M, et al. Among authors: sakurai m. J Med Chem. 2008 Mar 27;51(6):1925-44. doi: 10.1021/jm701324c. Epub 2008 Feb 29. J Med Chem. 2008. PMID: 18307290
Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.
Imanishi M, Itou S, Washizuka K, Hamashima H, Nakajima Y, Araki T, Tomishima Y, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K. Imanishi M, et al. Among authors: sakurai m. J Med Chem. 2008 Jul 10;51(13):4002-20. doi: 10.1021/jm8000345. Epub 2008 Jun 14. J Med Chem. 2008. PMID: 18553954
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.
Nakajima Y, Imanishi M, Itou S, Hamashima H, Tomishima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Hattori K. Nakajima Y, et al. Among authors: sakurai m. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5037-40. doi: 10.1016/j.bmcl.2008.08.009. Epub 2008 Aug 7. Bioorg Med Chem Lett. 2008. PMID: 18752946
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.
Hattori K, Toda S, Imanishi M, Itou S, Nakajima Y, Washizuka K, Araki T, Hamashima H, Tomishima Y, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F. Hattori K, et al. Among authors: sakurai m. J Med Chem. 2009 May 14;52(9):3063-72. doi: 10.1021/jm9000709. J Med Chem. 2009. PMID: 19366244
Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.
Hattori K, Orita M, Toda S, Imanishi M, Itou S, Nakajima Y, Tanabe D, Washizuka K, Araki T, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F. Hattori K, et al. Among authors: sakurai m. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4679-83. doi: 10.1016/j.bmcl.2009.06.083. Epub 2009 Jun 25. Bioorg Med Chem Lett. 2009. PMID: 19608416
2,149 results