Burnett JC - Search Results

1

Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.

Solaja BA, Opsenica D, Smith KS, Milhous WK, Terzić N, Opsenica I, Burnett JC, Nuss J, Gussio R, Bavari S. Solaja BA, et al. Among authors: burnett jc. J Med Chem. 2008 Aug 14;51(15):4388-91. doi: 10.1021/jm800737y. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637666

2

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S. Burnett JC, et al. J Med Chem. 2007 May 3;50(9):2127-36. doi: 10.1021/jm061446e. Epub 2007 Apr 7. J Med Chem. 2007. PMID: 17417831

3

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Opsenica I, Burnett JC, Gussio R, Opsenica D, Todorović N, Lanteri CA, Sciotti RJ, Gettayacamin M, Basilico N, Taramelli D, Nuss JE, Wanner L, Panchal RG, Solaja BA, Bavari S. Opsenica I, et al. Among authors: burnett jc. J Med Chem. 2011 Mar 10;54(5):1157-69. doi: 10.1021/jm100938u. Epub 2011 Jan 25. J Med Chem. 2011. PMID: 21265542 Free PMC article.

4

The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.

Opsenica I, Filipovic V, Nuss JE, Gomba LM, Opsenica D, Burnett JC, Gussio R, Solaja BA, Bavari S. Opsenica I, et al. Among authors: burnett jc. Eur J Med Chem. 2012 Jul;53:374-9. doi: 10.1016/j.ejmech.2012.03.043. Epub 2012 Mar 30. Eur J Med Chem. 2012. PMID: 22516424 Free PMC article.

5

4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.

Opsenica IM, Tot M, Gomba L, Nuss JE, Sciotti RJ, Bavari S, Burnett JC, Solaja BA. Opsenica IM, et al. Among authors: burnett jc. J Med Chem. 2013 Jul 25;56(14):5860-71. doi: 10.1021/jm4006077. Epub 2013 Jul 12. J Med Chem. 2013. PMID: 23815186 Free PMC article.

6

Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.

Videnović M, Opsenica DM, Burnett JC, Gomba L, Nuss JE, Selaković Z, Konstantinović J, Krstić M, Segan S, Zlatović M, Sciotti RJ, Bavari S, Solaja BA. Videnović M, et al. Among authors: burnett jc. J Med Chem. 2014 May 22;57(10):4134-53. doi: 10.1021/jm500033r. Epub 2014 May 1. J Med Chem. 2014. PMID: 24742203 Free PMC article.

7

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.

Burnett JC, Wang C, Nuss JE, Nguyen TL, Hermone AR, Schmidt JJ, Gussio R, Wipf P, Bavari S. Burnett JC, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5811-3. doi: 10.1016/j.bmcl.2009.01.111. Epub 2009 Feb 13. Bioorg Med Chem Lett. 2009. PMID: 19703771

8

Correlation between structure, retention, property, and activity of biologically relevant 1,7-bis(aminoalkyl)diazachrysene derivatives.

Šegan S, Trifković J, Verbić T, Opsenica D, Zlatović M, Burnett J, Šolaja B, Milojković-Opsenica D. Šegan S, et al. J Pharm Biomed Anal. 2013 Jan;72:231-9. doi: 10.1016/j.jpba.2012.08.025. Epub 2012 Aug 27. J Pharm Biomed Anal. 2013. PMID: 22985530

9

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S. Burnett JC, et al. Bioorg Med Chem. 2005 Jan 17;13(2):333-41. doi: 10.1016/j.bmc.2004.10.026. Bioorg Med Chem. 2005. PMID: 15598556

10

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.

Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, Bavari S. Burnett JC, et al. J Biol Chem. 2007 Feb 16;282(7):5004-5014. doi: 10.1074/jbc.M608166200. Epub 2006 Nov 8. J Biol Chem. 2007. PMID: 17092934 Free article.

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