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109 results

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Page 1
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Williams A, et al. Among authors: floto ra. Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79. Nat Chem Biol. 2008. PMID: 18391949 Free PMC article.
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.
Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA. Schiebler M, et al. Among authors: floto ra. EMBO Mol Med. 2015 Feb;7(2):127-39. doi: 10.15252/emmm.201404137. EMBO Mol Med. 2015. PMID: 25535254 Free PMC article.
A Rapid Unraveling of the Activity and Antibiotic Susceptibility of Mycobacteria.
Mustazzolu A, Venturelli L, Dinarelli S, Brown K, Floto RA, Dietler G, Fattorini L, Kasas S, Girasole M, Longo G. Mustazzolu A, et al. Among authors: floto ra. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02194-18. doi: 10.1128/AAC.02194-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30602518 Free PMC article.
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.
Thomas SE, Whitehouse AJ, Brown K, Burbaud S, Belardinelli JM, Sangen J, Lahiri R, Libardo MDJ, Gupta P, Malhotra S, Boshoff HIM, Jackson M, Abell C, Coyne AG, Blundell TL, Floto RA, Mendes V. Thomas SE, et al. Among authors: floto ra. Nucleic Acids Res. 2020 Aug 20;48(14):8099-8112. doi: 10.1093/nar/gkaa539. Nucleic Acids Res. 2020. PMID: 32602532 Free PMC article.
Microbial metabolism disrupts cytokine activity to impact host immune response.
Marshall EKP, Nunes C, Burbaud S, Vincent CM, Munroe NO, Simoes da Silva CJ, Wadhawan A, Pearson WH, Sangen J, Boeck L, Floto RA, S Dionne M. Marshall EKP, et al. Among authors: floto ra. Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2405719121. doi: 10.1073/pnas.2405719121. Epub 2024 Nov 8. Proc Natl Acad Sci U S A. 2024. PMID: 39514319 Free PMC article.
Global genomic surveillance of monkeypox virus.
Otieno JR, Ruis C, Onoja AB, Kuppalli K, Hoxha A, Nitsche A, Brinkmann A, Michel J, Mbala-Kingebeni P, Mukadi-Bamuleka D, Osman MM, Hussein H, Raja MA, Fotsing R, Herring BL, Keita M, Rico JM, Gresh L, Barakat A, Katawera V, Nahapetyan K, Naidoo D, Floto RA, Cunningham J, Van Kerkhove MD, Lewis RF, Subissi L. Otieno JR, et al. Among authors: floto ra. Nat Med. 2024 Oct 23. doi: 10.1038/s41591-024-03370-3. Online ahead of print. Nat Med. 2024. PMID: 39442559
Evolution and host-specific adaptation of Pseudomonas aeruginosa.
Weimann A, Dinan AM, Ruis C, Bernut A, Pont S, Brown K, Ryan J, Santos L, Ellison L, Ukor E, Pandurangan AP, Krokowski S, Blundell TL, Welch M, Blane B, Judge K, Bousfield R, Brown N, Bryant JM, Kukavica-Ibrulj I, Rampioni G, Leoni L, Harrison PT, Peacock SJ, Thomson NR, Gauthier J, Fothergill JL, Levesque RC, Parkhill J, Floto RA. Weimann A, et al. Among authors: floto ra. Science. 2024 Jul 5;385(6704):eadi0908. doi: 10.1126/science.adi0908. Epub 2024 Jul 5. Science. 2024. PMID: 38963857
109 results