El-Kabbani O - Search Results

1

Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid.

Dhagat U, Endo S, Sumii R, Hara A, El-Kabbani O. Dhagat U, et al. J Med Chem. 2008 Aug 14;51(15):4844-8. doi: 10.1021/jm8003575. Epub 2008 Jul 12. J Med Chem. 2008. PMID: 18620380

2

Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme.

Carbone V, Darmanin C, Ishikura S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1469-74. doi: 10.1016/s0960-894x(03)00166-5. Bioorg Med Chem Lett. 2003. PMID: 12668014

3

Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking.

Carbone V, Ishikura S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem. 2005 Jan 17;13(2):301-12. doi: 10.1016/j.bmc.2004.10.030. Bioorg Med Chem. 2005. PMID: 15598553

4

Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.

Carbone V, Endo S, Sumii R, Chung RP, Matsunaga T, Hara A, El-Kabbani O. Carbone V, et al. Proteins. 2008 Jan 1;70(1):176-87. doi: 10.1002/prot.21566. Proteins. 2008. PMID: 17654552

5

Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.

Dhagat U, Carbone V, Chung RP, Schulze-Briese C, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):825-30. doi: 10.1107/S1744309107040985. Epub 2007 Sep 19. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17909281 Free PMC article.

6

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.

Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Med Chem. 2007 Nov;3(6):546-50. doi: 10.2174/157340607782360399. Med Chem. 2007. PMID: 18045204

7

Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.

Dhagat U, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Bioorg Med Chem. 2008 Mar 15;16(6):3245-54. doi: 10.1016/j.bmc.2007.12.016. Epub 2007 Dec 15. Bioorg Med Chem. 2008. PMID: 18165015

8

Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.

Carbone V, Sumii R, Ishikura S, Asada Y, Hara A, El-Kabbani O. Carbone V, et al. Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):532-42. doi: 10.1107/S0907444908004538. Epub 2008 Apr 19. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18453689

9

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Carbone V, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Arch Biochem Biophys. 2008 Nov 1;479(1):82-7. doi: 10.1016/j.abb.2008.08.014. Epub 2008 Aug 28. Arch Biochem Biophys. 2008. PMID: 18782556

10

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.

Carbone V, Zhao HT, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. doi: 10.1016/j.bmc.2008.12.024. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19121944

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