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AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.
Fukushima-Shintani M, Suzuki K, Iwatsuki Y, Abe M, Sugasawa K, Hirayama F, Kawasaki T, Nakahata T. Fukushima-Shintani M, et al. Among authors: iwatsuki y. Eur J Haematol. 2009 Apr;82(4):247-54. doi: 10.1111/j.1600-0609.2008.01198.x. Epub 2009 Jan 16. Eur J Haematol. 2009. PMID: 19183407
Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.
Hirayama F, Koshio H, Ishihara T, Hachiya S, Sugasawa K, Koga Y, Seki N, Shiraki R, Shigenaga T, Iwatsuki Y, Moritani Y, Mori K, Kadokura T, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S. Hirayama F, et al. Among authors: iwatsuki y. J Med Chem. 2011 Dec 8;54(23):8051-65. doi: 10.1021/jm200868m. Epub 2011 Nov 11. J Med Chem. 2011. PMID: 21995444
Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors.
Ishihara T, Seki N, Hirayama F, Orita M, Koshio H, Taniuchi Y, Sakai-Moritani Y, Iwatsuki Y, Kaku S, Kawasaki T, Matsumoto Y, Tsukamoto S. Ishihara T, et al. Among authors: iwatsuki y. Bioorg Med Chem. 2007 Jun 15;15(12):4175-92. doi: 10.1016/j.bmc.2007.03.066. Epub 2007 Mar 25. Bioorg Med Chem. 2007. PMID: 17416533
Darexaban: anticoagulant effects in mice and human plasma in vitro, antithrombotic effects in thrombosis and bleeding models in mice and effects of anti-inhibitor coagulant complex and recombinant factor VIIa.
Kaku S, Suzuki M, Saitoh M, Funatsu T, Uemura T, Suzuki K, Iwatsuki Y, Kawasaki T. Kaku S, et al. Among authors: iwatsuki y. Thromb Res. 2013 May;131(5):450-6. doi: 10.1016/j.thromres.2013.03.016. Epub 2013 Apr 13. Thromb Res. 2013. PMID: 23591155
36 results