Backer JM - Search Results

1

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats.

Ono H, Pocai A, Wang Y, Sakoda H, Asano T, Backer JM, Schwartz GJ, Rossetti L. Ono H, et al. Among authors: backer jm. J Clin Invest. 2008 Aug;118(8):2959-68. doi: 10.1172/JCI34277. J Clin Invest. 2008. PMID: 18618016 Free PMC article.

2

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.

Byfield MP, Murray JT, Backer JM. Byfield MP, et al. Among authors: backer jm. J Biol Chem. 2005 Sep 23;280(38):33076-82. doi: 10.1074/jbc.M507201200. Epub 2005 Jul 27. J Biol Chem. 2005. PMID: 16049009 Free article.

3

The late endosome is essential for mTORC1 signaling.

Flinn RJ, Yan Y, Goswami S, Parker PJ, Backer JM. Flinn RJ, et al. Among authors: backer jm. Mol Biol Cell. 2010 Mar 1;21(5):833-41. doi: 10.1091/mbc.e09-09-0756. Epub 2010 Jan 6. Mol Biol Cell. 2010. PMID: 20053679 Free PMC article.

4

Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM. Dbouk HA, et al. Among authors: backer jm. PLoS One. 2013 May 29;8(5):e63833. doi: 10.1371/journal.pone.0063833. Print 2013. PLoS One. 2013. PMID: 23734178 Free PMC article.

5

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E. Braccini L, et al. Among authors: backer jm. Nat Commun. 2015 Jun 23;6:7400. doi: 10.1038/ncomms8400. Nat Commun. 2015. PMID: 26100075 Free PMC article.

6

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.

Shekar SC, Wu H, Fu Z, Yip SC, Nagajyothi, Cahill SM, Girvin ME, Backer JM. Shekar SC, et al. Among authors: backer jm. J Biol Chem. 2005 Jul 29;280(30):27850-5. doi: 10.1074/jbc.M506005200. Epub 2005 Jun 2. J Biol Chem. 2005. PMID: 15932879 Free article.

7

Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells.

El-Sibai M, Backer JM. El-Sibai M, et al. Among authors: backer jm. Eur J Immunol. 2007 Jan;37(1):261-70. doi: 10.1002/eji.200635875. Eur J Immunol. 2007. PMID: 17163445 Free article.

8

The regulation and function of Class III PI3Ks: novel roles for Vps34.

Backer JM. Backer JM. Biochem J. 2008 Feb 15;410(1):1-17. doi: 10.1042/BJ20071427. Biochem J. 2008. PMID: 18215151 Review.

9

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.

Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B. Weinger JG, et al. Among authors: backer jm. J Neurochem. 2008 Jul;106(1):134-46. doi: 10.1111/j.1471-4159.2008.05343.x. Epub 2008 Jul 1. J Neurochem. 2008. PMID: 18346204 Free PMC article.

10

The regulation of class IA PI 3-kinases by inter-subunit interactions.

Backer JM. Backer JM. Curr Top Microbiol Immunol. 2010;346:87-114. doi: 10.1007/82_2010_52. Curr Top Microbiol Immunol. 2010. PMID: 20544340 Free PMC article. Review.

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