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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J. Vince JE, et al. Among authors: wong ww. Cell. 2007 Nov 16;131(4):682-93. doi: 10.1016/j.cell.2007.10.037. Cell. 2007. PMID: 18022363 Free article.
CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.
Ahmed AU, Moulin M, Coumailleau F, Wong WW, Miasari M, Carter H, Silke J, Cohen-Tannoudji M, Vince JE, Vaux DL. Ahmed AU, et al. Among authors: wong ww. Curr Biol. 2009 Jan 13;19(1):R15-7; author reply R17-9. doi: 10.1016/j.cub.2008.11.040. Curr Biol. 2009. PMID: 19138581 Free article. No abstract available.
Another facet of ubiquitylation: death.
Wong WW, Silke J. Wong WW, et al. J Mol Cell Biol. 2009 Dec;1(2):80-1. doi: 10.1093/jmcb/mjp019. Epub 2009 Sep 30. J Mol Cell Biol. 2009. PMID: 19797318
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
Vince JE, Pantaki D, Feltham R, Mace PD, Cordier SM, Schmukle AC, Davidson AJ, Callus BA, Wong WW, Gentle IE, Carter H, Lee EF, Walczak H, Day CL, Vaux DL, Silke J. Vince JE, et al. Among authors: wong ww. J Biol Chem. 2009 Dec 18;284(51):35906-15. doi: 10.1074/jbc.M109.072256. J Biol Chem. 2009. PMID: 19815541 Free PMC article.
Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.
Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J. Feltham R, et al. Among authors: wong ww. J Biol Chem. 2010 Jun 4;285(23):17525-36. doi: 10.1074/jbc.M109.087635. Epub 2010 Mar 30. J Biol Chem. 2010. PMID: 20356846 Free PMC article.
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. Gentle IE, et al. Among authors: wong ww. J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. J Biol Chem. 2011. PMID: 21339290 Free PMC article.
IAPs limit activation of RIP kinases by TNF receptor 1 during development.
Moulin M, Anderton H, Voss AK, Thomas T, Wong WW, Bankovacki A, Feltham R, Chau D, Cook WD, Silke J, Vaux DL. Moulin M, et al. Among authors: wong ww. EMBO J. 2012 Apr 4;31(7):1679-91. doi: 10.1038/emboj.2012.18. Epub 2012 Feb 10. EMBO J. 2012. PMID: 22327219 Free PMC article.
874 results