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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.
Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, Bose S, McCarthy D, Zhu RR, Santora L, Davis-Taber R, Kunes Y, Fung E, Schwartz A, Sakorafas P, Gu J, Tarcsa E, Murtaza A, Ghayur T. Wu C, et al. Among authors: fung e. Nat Biotechnol. 2007 Nov;25(11):1290-7. doi: 10.1038/nbt1345. Epub 2007 Oct 14. Nat Biotechnol. 2007. PMID: 17934452
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models.
Huang L, Fung E, Bose S, Popp A, Böser P, Memmott J, Kutskova YA, Miller R, Tarcsa E, Klein C, Veldman GM, Mueller BK, Cui YF. Huang L, et al. Among authors: fung e. Neurobiol Dis. 2021 Nov;159:105492. doi: 10.1016/j.nbd.2021.105492. Epub 2021 Aug 31. Neurobiol Dis. 2021. PMID: 34478849 Free article.
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion.
Jacobson PB, Mothe A, Levy A, Krakovsky M, Hooker BA, Zhang X, Mollon J, Mordashova Y, Droescher M, Weiss S, Barghorn S, Dreher I, Awwad K, Nimmrich V, Huang L, Fung E, Buck WR, Pfleeger K, Ziemann A, Smith E, Fox GB, Tator CH, Gold M. Jacobson PB, et al. Among authors: fung e. Transl Stroke Res. 2024 Aug;15(4):805-817. doi: 10.1007/s12975-023-01164-2. Epub 2023 Jun 16. Transl Stroke Res. 2024. PMID: 37326791 Free PMC article.
580 results