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Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila.
Wloga D, Rogowski K, Sharma N, Van Dijk J, Janke C, Eddé B, Bré MH, Levilliers N, Redeker V, Duan J, Gorovsky MA, Jerka-Dziadosz M, Gaertig J. Wloga D, et al. Among authors: janke c. Eukaryot Cell. 2008 Aug;7(8):1362-72. doi: 10.1128/EC.00084-08. Epub 2008 Jun 27. Eukaryot Cell. 2008. PMID: 18586949 Free PMC article.
Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B. Janke C, et al. Science. 2005 Jun 17;308(5729):1758-62. doi: 10.1126/science.1113010. Epub 2005 May 12. Science. 2005. PMID: 15890843
TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia.
Wloga D, Webster DM, Rogowski K, Bré MH, Levilliers N, Jerka-Dziadosz M, Janke C, Dougan ST, Gaertig J. Wloga D, et al. Among authors: janke c. Dev Cell. 2009 Jun;16(6):867-76. doi: 10.1016/j.devcel.2009.04.008. Dev Cell. 2009. PMID: 19531357 Free article.
Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
Lacroix B, van Dijk J, Gold ND, Guizetti J, Aldrian-Herrada G, Rogowski K, Gerlich DW, Janke C. Lacroix B, et al. Among authors: janke c. J Cell Biol. 2010 Jun 14;189(6):945-54. doi: 10.1083/jcb.201001024. Epub 2010 Jun 7. J Cell Biol. 2010. PMID: 20530212 Free PMC article.
207 results