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Page 1
Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms.
Harrison A, Gardner I, Hay T, Dickins M, Beaumont K, Phipps A, Purkins L, Allan G, Christian R, Duckworth J, Gurrell I, Kempshall S, Savage M, Seymour M, Simpson M, Taylor L, Turnpenny P. Harrison A, et al. Among authors: dickins m. Xenobiotica. 2012 Jan;42(1):57-74. doi: 10.3109/00498254.2011.622418. Epub 2011 Oct 12. Xenobiotica. 2012. PMID: 21992032 Clinical Trial.
Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling.
Jones HM, Gardner IB, Collard WT, Stanley PJ, Oxley P, Hosea NA, Plowchalk D, Gernhardt S, Lin J, Dickins M, Rahavendran SR, Jones BC, Watson KJ, Pertinez H, Kumar V, Cole S. Jones HM, et al. Among authors: dickins m. Clin Pharmacokinet. 2011 May;50(5):331-47. doi: 10.2165/11539680-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21456633
Application of PBPK modelling in drug discovery and development at Pfizer.
Jones HM, Dickins M, Youdim K, Gosset JR, Attkins NJ, Hay TL, Gurrell IK, Logan YR, Bungay PJ, Jones BC, Gardner IB. Jones HM, et al. Among authors: dickins m. Xenobiotica. 2012 Jan;42(1):94-106. doi: 10.3109/00498254.2011.627477. Epub 2011 Oct 30. Xenobiotica. 2012. PMID: 22035569
Maraviroc: in vitro assessment of drug-drug interaction potential.
Hyland R, Dickins M, Collins C, Jones H, Jones B. Hyland R, et al. Among authors: dickins m. Br J Clin Pharmacol. 2008 Oct;66(4):498-507. doi: 10.1111/j.1365-2125.2008.03198.x. Epub 2008 Apr 10. Br J Clin Pharmacol. 2008. PMID: 18647303 Free PMC article.
Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.
Youdim KA, Zayed A, Dickins M, Phipps A, Griffiths M, Darekar A, Hyland R, Fahmi O, Hurst S, Plowchalk DR, Cook J, Guo F, Obach RS. Youdim KA, et al. Among authors: dickins m. Br J Clin Pharmacol. 2008 May;65(5):680-92. doi: 10.1111/j.1365-2125.2007.03070.x. Epub 2008 Feb 14. Br J Clin Pharmacol. 2008. PMID: 18279465 Free PMC article.
Induction of cytochromes P450.
Dickins M. Dickins M. Curr Top Med Chem. 2004;4(16):1745-66. doi: 10.2174/1568026043387115. Curr Top Med Chem. 2004. PMID: 15579106 Review.
The importance of predictive ADME simulation.
Dickins M, Modi S. Dickins M, et al. Drug Discov Today. 2002 Jul 15;7(14):755-6. doi: 10.1016/s1359-6446(02)02357-7. Drug Discov Today. 2002. PMID: 12547029 No abstract available.
84 results