Roberts GC - Search Results

1

Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.

Liénard BM, Garau G, Horsfall L, Karsisiotis AI, Damblon C, Lassaux P, Papamicael C, Roberts GC, Galleni M, Dideberg O, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: roberts gc. Org Biomol Chem. 2008 Jul 7;6(13):2282-94. doi: 10.1039/b802311e. Epub 2008 May 7. Org Biomol Chem. 2008. PMID: 18563261

2

Complete ¹H, ¹⁵N, and ¹³C resonance assignments of Bacillus cereus metallo-β-lactamase and its complex with the inhibitor R-thiomandelic acid.

Karsisiotis AI, Damblon C, Roberts GC. Karsisiotis AI, et al. Among authors: roberts gc. Biomol NMR Assign. 2014 Oct;8(2):313-8. doi: 10.1007/s12104-013-9507-1. Epub 2013 Jul 10. Biomol NMR Assign. 2014. PMID: 23838816 Free PMC article.

3

A variety of roles for versatile zinc in metallo-β-lactamases.

Karsisiotis AI, Damblon CF, Roberts GC. Karsisiotis AI, et al. Among authors: roberts gc. Metallomics. 2014 Jul;6(7):1181-97. doi: 10.1039/c4mt00066h. Metallomics. 2014. PMID: 24696003 Review.

4

The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding.

Damblon C, Jensen M, Ababou A, Barsukov I, Papamicael C, Schofield CJ, Olsen L, Bauer R, Roberts GC. Damblon C, et al. Among authors: roberts gc. J Biol Chem. 2003 Aug 1;278(31):29240-51. doi: 10.1074/jbc.M301562200. Epub 2003 Apr 29. J Biol Chem. 2003. PMID: 12724330 Free article.

5

Solution structures of the Bacillus cereus metallo-β-lactamase BcII and its complex with the broad spectrum inhibitor R-thiomandelic acid.

Karsisiotis AI, Damblon CF, Roberts GC. Karsisiotis AI, et al. Among authors: roberts gc. Biochem J. 2013 Dec 15;456(3):397-407. doi: 10.1042/BJ20131003. Biochem J. 2013. PMID: 24059435 Free PMC article.

6

Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies.

Mollard C, Moali C, Papamicael C, Damblon C, Vessilier S, Amicosante G, Schofield CJ, Galleni M, Frere JM, Roberts GC. Mollard C, et al. Among authors: roberts gc. J Biol Chem. 2001 Nov 30;276(48):45015-23. doi: 10.1074/jbc.M107054200. Epub 2001 Sep 19. J Biol Chem. 2001. PMID: 11564740 Free article.

7

The Role of Active Site Flexible Loops in Catalysis and of Zinc in Conformational Stability of Bacillus cereus 569/H/9 β-Lactamase.

Montagner C, Nigen M, Jacquin O, Willet N, Dumoulin M, Karsisiotis AI, Roberts GC, Damblon C, Redfield C, Matagne A. Montagner C, et al. Among authors: roberts gc. J Biol Chem. 2016 Jul 29;291(31):16124-37. doi: 10.1074/jbc.M116.719005. Epub 2016 May 27. J Biol Chem. 2016. PMID: 27235401 Free PMC article.

8

Positively cooperative binding of zinc ions to Bacillus cereus 569/H/9 beta-lactamase II suggests that the binuclear enzyme is the only relevant form for catalysis.

Jacquin O, Balbeur D, Damblon C, Marchot P, De Pauw E, Roberts GC, Frère JM, Matagne A. Jacquin O, et al. Among authors: roberts gc. J Mol Biol. 2009 Oct 9;392(5):1278-91. doi: 10.1016/j.jmb.2009.07.092. Epub 2009 Aug 6. J Mol Biol. 2009. PMID: 19665032

9

The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.

Damblon C, Raquet X, Lian LY, Lamotte-Brasseur J, Fonze E, Charlier P, Roberts GC, Frère JM. Damblon C, et al. Among authors: roberts gc. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1747-52. doi: 10.1073/pnas.93.5.1747. Proc Natl Acad Sci U S A. 1996. PMID: 8700829 Free PMC article.

10

Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase.

Jamin M, Damblon C, Bauduin-Misselyn AM, Durant F, Roberts GC, Charlier P, Llabres G, Frère JM. Jamin M, et al. Among authors: roberts gc. Biochem J. 1994 Jul 1;301 ( Pt 1)(Pt 1):199-203. doi: 10.1042/bj3010199. Biochem J. 1994. PMID: 8037671 Free PMC article.

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