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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.
Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW. Wood-Kaczmar A, et al. Among authors: downward j. PLoS One. 2008 Jun 18;3(6):e2455. doi: 10.1371/journal.pone.0002455. PLoS One. 2008. PMID: 18560593 Free PMC article.
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J. Martins LM, et al. Among authors: downward j. Mol Cell Biol. 2004 Nov;24(22):9848-62. doi: 10.1128/MCB.24.22.9848-9862.2004. Mol Cell Biol. 2004. PMID: 15509788 Free PMC article.
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.
Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwards RE, Teismann P, Esposti MD, Morrison AD, Wood NW, Downward J, Martins LM. Moisoi N, et al. Among authors: downward j. Cell Death Differ. 2009 Mar;16(3):449-64. doi: 10.1038/cdd.2008.166. Epub 2008 Nov 21. Cell Death Differ. 2009. PMID: 19023330
Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis.
Pardo OE, Arcaro A, Salerno G, Raguz S, Downward J, Seckl MJ. Pardo OE, et al. Among authors: downward j. J Biol Chem. 2002 Apr 5;277(14):12040-6. doi: 10.1074/jbc.M109006200. Epub 2002 Jan 28. J Biol Chem. 2002. Retraction in: J Biol Chem. 2015 Jun 19;290(25):15390. doi: 10.1074/jbc.A115.109006 PMID: 11815602 Free article. Retracted.
305 results