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A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins.
Destouches D, Page N, Hamma-Kourbali Y, Machi V, Chaloin O, Frechault S, Birmpas C, Katsoris P, Beyrath J, Albanese P, Maurer M, Carpentier G, Strub JM, Van Dorsselaer A, Muller S, Bagnard D, Briand JP, Courty J. Destouches D, et al. Cancer Res. 2011 May 1;71(9):3296-305. doi: 10.1158/0008-5472.CAN-10-3459. Epub 2011 Mar 17. Cancer Res. 2011. PMID: 21415166 Free article.
Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model.
Benedetti E, Antonosante A, d'Angelo M, Cristiano L, Galzio R, Destouches D, Florio TM, Dhez AC, Astarita C, Cinque B, Fidoamore A, Rosati F, Cifone MG, Ippoliti R, Giordano A, Courty J, Cimini A. Benedetti E, et al. Among authors: d angelo m, destouches d. Oncotarget. 2015 Dec 8;6(39):42091-104. doi: 10.18632/oncotarget.5990. Oncotarget. 2015. PMID: 26540346 Free PMC article.
Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature.
Gilles ME, Maione F, Cossutta M, Carpentier G, Caruana L, Di Maria S, Houppe C, Destouches D, Shchors K, Prochasson C, Mongelard F, Lamba S, Bardelli A, Bouvet P, Couvelard A, Courty J, Giraudo E, Cascone I. Gilles ME, et al. Among authors: destouches d. Cancer Res. 2016 Dec 15;76(24):7181-7193. doi: 10.1158/0008-5472.CAN-16-0300. Epub 2016 Oct 17. Cancer Res. 2016. PMID: 27754848 Free article.
N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy.
De Cola A, Franceschini M, Di Matteo A, Colotti G, Celani R, Clemente E, Ippoliti R, Cimini AM, Dhez AC, Vallée B, Raineri F, Cascone I, Destouches D, De Laurenzi V, Courty J, Federici L. De Cola A, et al. Among authors: destouches d. Cancer Lett. 2018 Jan 1;412:272-282. doi: 10.1016/j.canlet.2017.10.038. Epub 2017 Oct 27. Cancer Lett. 2018. PMID: 29111347 Free article.
Multivalent cationic pseudopeptide polyplexes as a tool for cancer therapy.
Diamantopoulou Z, Gilles ME, Sader M, Cossutta M, Vallée B, Houppe C, Habert D, Brissault B, Leroy E, Maione F, Giraudo E, Destouches D, Penelle J, Courty J, Cascone I. Diamantopoulou Z, et al. Among authors: destouches d. Oncotarget. 2017 Sep 30;8(52):90108-90122. doi: 10.18632/oncotarget.21441. eCollection 2017 Oct 27. Oncotarget. 2017. PMID: 29163814 Free PMC article.
23 results