Wang CE - Search Results

1

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. Wang CE, et al. Hum Mol Genet. 2008 Sep 1;17(17):2738-51. doi: 10.1093/hmg/ddn175. Epub 2008 Jun 16. Hum Mol Genet. 2008. PMID: 18558632 Free PMC article.

2

Polyglutamine expansion of huntingtin impairs its nuclear export.

Cornett J, Cao F, Wang CE, Ross CA, Bates GP, Li SH, Li XJ. Cornett J, et al. Among authors: wang ce. Nat Genet. 2005 Feb;37(2):198-204. doi: 10.1038/ng1503. Epub 2005 Jan 16. Nat Genet. 2005. PMID: 15654337

3

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity.

Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ. Shin JY, et al. Among authors: wang ce. J Cell Biol. 2005 Dec 19;171(6):1001-12. doi: 10.1083/jcb.200508072. J Cell Biol. 2005. PMID: 16365166 Free PMC article.

4

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ. Orr AL, et al. Among authors: wang ce, wang j. J Neurosci. 2008 Mar 12;28(11):2783-92. doi: 10.1523/JNEUROSCI.0106-08.2008. J Neurosci. 2008. PMID: 18337408 Free PMC article.

5

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.

Wang J, Wang CE, Orr A, Tydlacka S, Li SH, Li XJ. Wang J, et al. Among authors: wang ce. J Cell Biol. 2008 Mar 24;180(6):1177-89. doi: 10.1083/jcb.200709080. J Cell Biol. 2008. PMID: 18362179 Free PMC article.

6

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons.

Tydlacka S, Wang CE, Wang X, Li S, Li XJ. Tydlacka S, et al. Among authors: wang x, wang ce. J Neurosci. 2008 Dec 3;28(49):13285-95. doi: 10.1523/JNEUROSCI.4393-08.2008. J Neurosci. 2008. PMID: 19052220 Free PMC article.

7

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.

Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S. Bradford J, et al. Among authors: wang ce. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22480-5. doi: 10.1073/pnas.0911503106. Epub 2009 Dec 11. Proc Natl Acad Sci U S A. 2009. PMID: 20018729 Free PMC article.

8

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.

Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ. Bradford J, et al. Among authors: wang ce. J Biol Chem. 2010 Apr 2;285(14):10653-61. doi: 10.1074/jbc.M109.083287. Epub 2010 Feb 9. J Biol Chem. 2010. PMID: 20145253 Free PMC article.

9

Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.

Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S. Li X, et al. Among authors: wang ce. Hum Mol Genet. 2010 Jun 15;19(12):2445-55. doi: 10.1093/hmg/ddq127. Epub 2010 Mar 30. Hum Mol Genet. 2010. PMID: 20354076 Free PMC article.

10

Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice.

Wang CE, Li S, Li XJ. Wang CE, et al. Mol Brain. 2010 Nov 2;3:33. doi: 10.1186/1756-6606-3-33. Mol Brain. 2010. PMID: 21044321 Free PMC article.

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