Lim HD - Search Results

1

Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations.

Jongejan A, Lim HD, Smits RA, de Esch IJ, Haaksma E, Leurs R. Jongejan A, et al. Among authors: lim hd. J Chem Inf Model. 2008 Jul;48(7):1455-63. doi: 10.1021/ci700474a. Epub 2008 Jun 14. J Chem Inf Model. 2008. PMID: 18553960

2

Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.

Wijtmans M, de Graaf C, de Kloe G, Istyastono EP, Smit J, Lim H, Boonnak R, Nijmeijer S, Smits RA, Jongejan A, Zuiderveld O, de Esch IJ, Leurs R. Wijtmans M, et al. J Med Chem. 2011 Mar 24;54(6):1693-703. doi: 10.1021/jm1013488. Epub 2011 Feb 24. J Med Chem. 2011. PMID: 21348462

3

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.

Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R. Lim HD, et al. J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. doi: 10.1124/jpet.105.087965. Epub 2005 Jun 9. J Pharmacol Exp Ther. 2005. PMID: 15947036

4

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor: effect of various substitutions at the primary amino function.

Govoni M, Lim HD, El-Atmioui D, Menge WM, Timmerman H, Bakker RA, Leurs R, De Esch IJ. Govoni M, et al. Among authors: lim hd. J Med Chem. 2006 Apr 20;49(8):2549-57. doi: 10.1021/jm0504353. J Med Chem. 2006. PMID: 16610798

5

Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.

Smits RA, Lim HD, Stegink B, Bakker RA, de Esch IJ, Leurs R. Smits RA, et al. Among authors: lim hd. J Med Chem. 2006 Jul 27;49(15):4512-6. doi: 10.1021/jm051008s. J Med Chem. 2006. PMID: 16854056

6

The emerging role of the histamine H4 receptor in anti-inflammatory therapy.

Lim HD, Smits RA, Leurs R, De Esch IJ. Lim HD, et al. Curr Top Med Chem. 2006;6(13):1365-73. doi: 10.2174/15680266106061365. Curr Top Med Chem. 2006. PMID: 16918455 Review.

7

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.

Lim HD, Smits RA, Bakker RA, van Dam CM, de Esch IJ, Leurs R. Lim HD, et al. J Med Chem. 2006 Nov 16;49(23):6650-1. doi: 10.1021/jm060880d. J Med Chem. 2006. PMID: 17154494

8

Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

Smits RA, Lim HD, Hanzer A, Zuiderveld OP, Guaita E, Adami M, Coruzzi G, Leurs R, de Esch IJ. Smits RA, et al. Among authors: lim hd. J Med Chem. 2008 Apr 24;51(8):2457-67. doi: 10.1021/jm7014217. Epub 2008 Mar 22. J Med Chem. 2008. PMID: 18357976

9

Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors.

Lim HD, Jongejan A, Bakker RA, Haaksma E, de Esch IJ, Leurs R. Lim HD, et al. J Pharmacol Exp Ther. 2008 Oct;327(1):88-96. doi: 10.1124/jpet.108.140343. Epub 2008 Jul 17. J Pharmacol Exp Ther. 2008. PMID: 18635748

10

Molecular and biochemical pharmacology of the histamine H4 receptor.

Leurs R, Chazot PL, Shenton FC, Lim HD, de Esch IJ. Leurs R, et al. Among authors: lim hd. Br J Pharmacol. 2009 May;157(1):14-23. doi: 10.1111/j.1476-5381.2009.00250.x. Br J Pharmacol. 2009. PMID: 19413568 Free PMC article. Review.

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