Leurs R - Search Results

1

Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations.

Jongejan A, Lim HD, Smits RA, de Esch IJ, Haaksma E, Leurs R. Jongejan A, et al. Among authors: leurs r. J Chem Inf Model. 2008 Jul;48(7):1455-63. doi: 10.1021/ci700474a. Epub 2008 Jun 14. J Chem Inf Model. 2008. PMID: 18553960

2

Histamine receptors: subclasses and specific ligands.

Haaksma EE, Leurs R, Timmerman H. Haaksma EE, et al. Among authors: leurs r. Pharmacol Ther. 1990;47(1):73-104. doi: 10.1016/0163-7258(90)90046-5. Pharmacol Ther. 1990. PMID: 2195558 Review.

3

Visualization of agonist-induced internalization of histamine H2 receptors.

Smit MJ, Timmerman H, Alewijnse AE, Punin M, van den Nieuwenhof I, Blauw J, van Minnen J, Leurs R. Smit MJ, et al. Among authors: leurs r. Biochem Biophys Res Commun. 1995 Sep 25;214(3):1138-45. doi: 10.1006/bbrc.1995.2404. Biochem Biophys Res Commun. 1995. PMID: 7575521

4

Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists.

Leurs R, Smit MJ, Meeder R, Ter Laak AM, Timmerman H. Leurs R, et al. Biochem Biophys Res Commun. 1995 Sep 5;214(1):110-7. doi: 10.1006/bbrc.1995.2263. Biochem Biophys Res Commun. 1995. PMID: 7669031

5

Site-directed mutagenesis of the histamine H1-receptor reveals a selective interaction of asparagine207 with subclasses of H1-receptor agonists.

Leurs R, Smit MJ, Tensen CP, Ter Laak AM, Timmerman H. Leurs R, et al. Biochem Biophys Res Commun. 1994 May 30;201(1):295-301. doi: 10.1006/bbrc.1994.1701. Biochem Biophys Res Commun. 1994. PMID: 8198587

6

Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.

ter Laak AM, Timmerman H, Leurs R, Nederkoorn PH, Smit MJ, Donné-Op den Kelder GM. ter Laak AM, et al. Among authors: leurs r. J Comput Aided Mol Des. 1995 Aug;9(4):319-30. doi: 10.1007/BF00125173. J Comput Aided Mol Des. 1995. PMID: 8523041

7

The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation.

Smit MJ, Timmerman H, Blauw J, Beukers MW, Roovers E, Jacobs EH, Hoffmann M, Leurs R. Smit MJ, et al. Among authors: leurs r. J Neurochem. 1996 Nov;67(5):1791-800. doi: 10.1046/j.1471-4159.1996.67051791.x. J Neurochem. 1996. PMID: 8863482

8

Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.

De Esch IJ, Vollinga RC, Goubitz K, Schenk H, Appelberg U, Hacksell U, Lemstra S, Zuiderveld OP, Hoffmann M, Leurs R, Menge WM, Timmerman H. De Esch IJ, et al. Among authors: leurs r. J Med Chem. 1999 Apr 8;42(7):1115-22. doi: 10.1021/jm9810912. J Med Chem. 1999. PMID: 10197956 Free article.

9

Mutational analysis of the antagonist-binding site of the histamine H(1) receptor.

Wieland K, Laak AM, Smit MJ, Kühne R, Timmerman H, Leurs R. Wieland K, et al. Among authors: leurs r. J Biol Chem. 1999 Oct 15;274(42):29994-30000. doi: 10.1074/jbc.274.42.29994. J Biol Chem. 1999. PMID: 10514483 Free article.

10

Constitutive activity of the histamine H(1) receptor reveals inverse agonism of histamine H(1) receptor antagonists.

Bakker RA, Wieland K, Timmerman H, Leurs R. Bakker RA, et al. Among authors: leurs r. Eur J Pharmacol. 2000 Jan 3;387(1):R5-7. doi: 10.1016/s0014-2999(99)00803-1. Eur J Pharmacol. 2000. PMID: 10633171

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

414 results

Search Page

Filters