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Tryptophan synthase: the workings of a channeling nanomachine.
Dunn MF, Niks D, Ngo H, Barends TR, Schlichting I. Dunn MF, et al. Among authors: schlichting i. Trends Biochem Sci. 2008 Jun;33(6):254-64. doi: 10.1016/j.tibs.2008.04.008. Epub 2008 May 15. Trends Biochem Sci. 2008. PMID: 18486479 Review.
Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding.
Casino P, Niks D, Ngo H, Pan P, Brzovic P, Blumenstein L, Barends TR, Schlichting I, Dunn MF. Casino P, et al. Among authors: schlichting i. Biochemistry. 2007 Jul 3;46(26):7728-39. doi: 10.1021/bi700386b. Epub 2007 Jun 9. Biochemistry. 2007. PMID: 17559231
The ASLs studied are alpha-d,l-glycerol phosphate (GP) and d-glyceraldehyde 3-phosphate (G3P), and examples of two new classes of high-affinity alpha-site ligands, N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate (F6) and N-(4'-trifluoromethoxybenzenesulfonyl)-2-aminoethyl p …
The ASLs studied are alpha-d,l-glycerol phosphate (GP) and d-glyceraldehyde 3-phosphate (G3P), and examples of two new classes of high-affin …
Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands.
Ngo H, Kimmich N, Harris R, Niks D, Blumenstein L, Kulik V, Barends TR, Schlichting I, Dunn MF. Ngo H, et al. Among authors: schlichting i. Biochemistry. 2007 Jul 3;46(26):7740-53. doi: 10.1021/bi7003872. Epub 2007 Jun 9. Biochemistry. 2007. PMID: 17559232
Within the beta-site, indole and l-Ser react with pyridoxal 5'-phosphate in a two-stage reaction to give l-Trp. In stage I, l-Ser forms an external aldimine, E(Aex1), which converts to the alpha-aminoacrylate aldimine, E(A-A). ...R., Kulik, V., Weyand, M., Schlichting …
Within the beta-site, indole and l-Ser react with pyridoxal 5'-phosphate in a two-stage reaction to give l-Trp. In stage I, l-Ser for …
Tryptophan synthase, an allosteric molecular factory.
Barends TR, Dunn MF, Schlichting I. Barends TR, et al. Among authors: schlichting i. Curr Opin Chem Biol. 2008 Oct;12(5):593-600. doi: 10.1016/j.cbpa.2008.07.011. Curr Opin Chem Biol. 2008. PMID: 18675375
218 results