Kim IH - Search Results

1

Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.

Olearczyk JJ, Quigley JE, Mitchell BC, Yamamoto T, Kim IH, Newman JW, Luria A, Hammock BD, Imig JD. Olearczyk JJ, et al. Among authors: kim ih. Clin Sci (Lond). 2009 Jan;116(1):61-70. doi: 10.1042/CS20080039. Clin Sci (Lond). 2009. PMID: 18459944 Free PMC article.

2

Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

Zhao X, Yamamoto T, Newman JW, Kim IH, Watanabe T, Hammock BD, Stewart J, Pollock JS, Pollock DM, Imig JD. Zhao X, et al. Among authors: kim ih. J Am Soc Nephrol. 2004 May;15(5):1244-53. J Am Soc Nephrol. 2004. PMID: 15100364

3

An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension.

Imig JD, Zhao X, Zaharis CZ, Olearczyk JJ, Pollock DM, Newman JW, Kim IH, Watanabe T, Hammock BD. Imig JD, et al. Among authors: kim ih. Hypertension. 2005 Oct;46(4):975-81. doi: 10.1161/01.HYP.0000176237.74820.75. Epub 2005 Sep 12. Hypertension. 2005. PMID: 16157792 Free PMC article.

4

Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels.

Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD. Olearczyk JJ, et al. Among authors: kim ih. J Pharmacol Exp Ther. 2006 Sep;318(3):1307-14. doi: 10.1124/jpet.106.103556. Epub 2006 Jun 13. J Pharmacol Exp Ther. 2006. PMID: 16772540

5

Soluble epoxide hydrolase is a therapeutic target for acute inflammation.

Schmelzer KR, Kubala L, Newman JW, Kim IH, Eiserich JP, Hammock BD. Schmelzer KR, et al. Among authors: kim ih. Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9772-7. doi: 10.1073/pnas.0503279102. Epub 2005 Jun 30. Proc Natl Acad Sci U S A. 2005. PMID: 15994227 Free PMC article.

6

Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors.

Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Schmelzer KR, et al. Among authors: kim ih. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13646-51. doi: 10.1073/pnas.0605908103. Epub 2006 Sep 1. Proc Natl Acad Sci U S A. 2006. PMID: 16950874 Free PMC article.

7

Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.

Kim IH, Morisseau C, Watanabe T, Hammock BD. Kim IH, et al. J Med Chem. 2004 Apr 8;47(8):2110-22. doi: 10.1021/jm030514j. J Med Chem. 2004. PMID: 15056008

8

Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension.

Jung O, Brandes RP, Kim IH, Schweda F, Schmidt R, Hammock BD, Busse R, Fleming I. Jung O, et al. Among authors: kim ih. Hypertension. 2005 Apr;45(4):759-65. doi: 10.1161/01.HYP.0000153792.29478.1d. Epub 2005 Feb 7. Hypertension. 2005. PMID: 15699457

9

Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase.

Kim IH, Nishi K, Tsai HJ, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. Kim IH, et al. Bioorg Med Chem. 2007 Jan 1;15(1):312-23. doi: 10.1016/j.bmc.2006.09.057. Epub 2006 Sep 29. Bioorg Med Chem. 2007. PMID: 17046265 Free PMC article.

10

Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation.

Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. Fife KL, et al. Among authors: kim ih. J Pharmacol Exp Ther. 2008 Dec;327(3):707-15. doi: 10.1124/jpet.108.142398. Epub 2008 Sep 24. J Pharmacol Exp Ther. 2008. PMID: 18815352 Free PMC article.

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