Blaha G - Search Results

1

Mutations outside the anisomycin-binding site can make ribosomes drug-resistant.

Blaha G, Gürel G, Schroeder SJ, Moore PB, Steitz TA. Blaha G, et al. J Mol Biol. 2008 Jun 6;379(3):505-19. doi: 10.1016/j.jmb.2008.03.075. Epub 2008 Apr 8. J Mol Biol. 2008. PMID: 18455733 Free PMC article.

2

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.

Tu D, Blaha G, Moore PB, Steitz TA. Tu D, et al. Among authors: blaha g. Cell. 2005 Apr 22;121(2):257-70. doi: 10.1016/j.cell.2005.02.005. Cell. 2005. PMID: 15851032 Free article.

3

Gene replacement in Haloarcula marismortui: construction of a strain with two of its three chromosomal rRNA operons deleted.

Tu D, Blaha G, Moore PB, Steitz TA. Tu D, et al. Among authors: blaha g. Extremophiles. 2005 Dec;9(6):427-35. doi: 10.1007/s00792-005-0459-y. Epub 2005 Jun 22. Extremophiles. 2005. PMID: 15970993

4

The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole.

Schroeder SJ, Blaha G, Tirado-Rives J, Steitz TA, Moore PB. Schroeder SJ, et al. Among authors: blaha g. J Mol Biol. 2007 Apr 13;367(5):1471-9. doi: 10.1016/j.jmb.2007.01.081. Epub 2007 Feb 7. J Mol Biol. 2007. PMID: 17321546 Free PMC article.

5

Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit.

Schroeder SJ, Blaha G, Moore PB. Schroeder SJ, et al. Among authors: blaha g. Antimicrob Agents Chemother. 2007 Dec;51(12):4462-5. doi: 10.1128/AAC.00455-07. Epub 2007 Jul 30. Antimicrob Agents Chemother. 2007. PMID: 17664317 Free PMC article.

6

U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.

Gürel G, Blaha G, Moore PB, Steitz TA. Gürel G, et al. Among authors: blaha g. J Mol Biol. 2009 May 29;389(1):146-56. doi: 10.1016/j.jmb.2009.04.005. Epub 2009 Apr 9. J Mol Biol. 2009. PMID: 19362093 Free PMC article.

7

Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome.

Blaha G, Stanley RE, Steitz TA. Blaha G, et al. Science. 2009 Aug 21;325(5943):966-70. doi: 10.1126/science.1175800. Science. 2009. PMID: 19696344 Free PMC article.

8

Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.

Gürel G, Blaha G, Steitz TA, Moore PB. Gürel G, et al. Among authors: blaha g. Antimicrob Agents Chemother. 2009 Dec;53(12):5010-4. doi: 10.1128/AAC.00817-09. Epub 2009 Sep 8. Antimicrob Agents Chemother. 2009. PMID: 19738021 Free PMC article.

9

The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.

Stanley RE, Blaha G, Grodzicki RL, Strickler MD, Steitz TA. Stanley RE, et al. Among authors: blaha g. Nat Struct Mol Biol. 2010 Mar;17(3):289-93. doi: 10.1038/nsmb.1755. Epub 2010 Feb 14. Nat Struct Mol Biol. 2010. PMID: 20154709 Free PMC article.

10

Revisiting the structures of several antibiotics bound to the bacterial ribosome.

Bulkley D, Innis CA, Blaha G, Steitz TA. Bulkley D, et al. Among authors: blaha g. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17158-63. doi: 10.1073/pnas.1008685107. Epub 2010 Sep 27. Proc Natl Acad Sci U S A. 2010. PMID: 20876130 Free PMC article.

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