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Page 1
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Sparey T, Abeywickrema P, Almond S, Brandon N, Byrne N, Campbell A, Hutson PH, Jacobson M, Jones B, Munshi S, Pascarella D, Pike A, Prasad GS, Sachs N, Sakatis M, Sardana V, Venkatraman S, Young MB. Sparey T, et al. Among authors: sakatis m. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3386-91. doi: 10.1016/j.bmcl.2008.04.020. Epub 2008 Apr 13. Bioorg Med Chem Lett. 2008. PMID: 18455394
Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury.
Schofield CA, Walker TM, Taylor MA, Patel M, Vlachou DF, Macina JM, Vidgeon-Hart MP, Williams A, McGill PJ, Newman CF, Sakatis MZ. Schofield CA, et al. Among authors: sakatis mz. Chem Res Toxicol. 2021 Dec 20;34(12):2485-2499. doi: 10.1021/acs.chemrestox.1c00227. Epub 2021 Nov 19. Chem Res Toxicol. 2021. PMID: 34797640
3D human tissue models and microphysiological systems for HIV and related comorbidities.
3D Human Tissue Models for HIV Working Group. Electronic address: dwight.yin@nih.gov; 3D Human Tissue Models for HIV Working Group. 3D Human Tissue Models for HIV Working Group. Electronic address: dwight.yin@nih.gov, et al. Trends Biotechnol. 2024 May;42(5):526-543. doi: 10.1016/j.tibtech.2023.10.008. Epub 2023 Dec 8. Trends Biotechnol. 2024. PMID: 38071144 Review.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Tomlinson L, Ramsden D, Leite SB, Beken S, Bonzo JA, Brown P, Candarlioglu PL, Chan TS, Chen E, Choi CK, David R, Delrue N, Devine PJ, Ford K, Garcia MI, Gosset JR, Hewitt P, Homan K, Irrechukwu O, Kopec AK, Liras JL, Mandlekar S, Raczynski A, Sadrieh N, Sakatis MZ, Siegel J, Sung K, Sunyovszki I, Van Vleet TR, Ekert JE, Hardwick RN. Tomlinson L, et al. Among authors: sakatis mz. Adv Biol (Weinh). 2024 Aug;8(8):e2300131. doi: 10.1002/adbi.202300131. Epub 2023 Oct 9. Adv Biol (Weinh). 2024. PMID: 37814378