Warby SC - Search Results

1

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.

Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR. Warby SC, et al. Hum Mol Genet. 2008 Aug 1;17(15):2390-404. doi: 10.1093/hmg/ddn139. Epub 2008 Apr 29. Hum Mol Genet. 2008. PMID: 18445618

2

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.

Warby SC, Chan EY, Metzler M, Gan L, Singaraja RR, Crocker SF, Robertson HA, Hayden MR. Warby SC, et al. Hum Mol Genet. 2005 Jun 1;14(11):1569-77. doi: 10.1093/hmg/ddi165. Epub 2005 Apr 20. Hum Mol Genet. 2005. PMID: 15843398

3

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Graham RK, et al. Among authors: warby sc. Cell. 2006 Jun 16;125(6):1179-91. doi: 10.1016/j.cell.2006.04.026. Cell. 2006. PMID: 16777606 Free article.

4

Selective degeneration in YAC mouse models of Huntington disease.

Van Raamsdonk JM, Warby SC, Hayden MR. Van Raamsdonk JM, et al. Among authors: warby sc. Brain Res Bull. 2007 Apr 30;72(2-3):124-31. doi: 10.1016/j.brainresbull.2006.10.018. Epub 2006 Nov 16. Brain Res Bull. 2007. PMID: 17352936 Review.

5

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.

Warby SC, Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR. Warby SC, et al. Mol Cell Neurosci. 2009 Feb;40(2):121-7. doi: 10.1016/j.mcn.2008.09.007. Epub 2008 Oct 18. Mol Cell Neurosci. 2009. PMID: 18992820

6

CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup.

Warby SC, Montpetit A, Hayden AR, Carroll JB, Butland SL, Visscher H, Collins JA, Semaka A, Hudson TJ, Hayden MR. Warby SC, et al. Am J Hum Genet. 2009 Mar;84(3):351-66. doi: 10.1016/j.ajhg.2009.02.003. Epub 2009 Feb 26. Am J Hum Genet. 2009. PMID: 19249009 Free PMC article.

7

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.

Warby SC, Visscher H, Collins JA, Doty CN, Carter C, Butland SL, Hayden AR, Kanazawa I, Ross CJ, Hayden MR. Warby SC, et al. Eur J Hum Genet. 2011 May;19(5):561-6. doi: 10.1038/ejhg.2010.229. Epub 2011 Jan 19. Eur J Hum Genet. 2011. PMID: 21248742 Free PMC article.

8

Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.

Carroll JB, Warby SC, Southwell AL, Doty CN, Greenlee S, Skotte N, Hung G, Bennett CF, Freier SM, Hayden MR. Carroll JB, et al. Among authors: warby sc. Mol Ther. 2011 Dec;19(12):2178-85. doi: 10.1038/mt.2011.201. Epub 2011 Oct 4. Mol Ther. 2011. PMID: 21971427 Free PMC article.

9

A fully humanized transgenic mouse model of Huntington disease.

Southwell AL, Warby SC, Carroll JB, Doty CN, Skotte NH, Zhang W, Villanueva EB, Kovalik V, Xie Y, Pouladi MA, Collins JA, Yang XW, Franciosi S, Hayden MR. Southwell AL, et al. Among authors: warby sc. Hum Mol Genet. 2013 Jan 1;22(1):18-34. doi: 10.1093/hmg/dds397. Epub 2012 Sep 21. Hum Mol Genet. 2013. PMID: 23001568 Free PMC article.

10

Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.

Skotte NH, Southwell AL, Østergaard ME, Carroll JB, Warby SC, Doty CN, Petoukhov E, Vaid K, Kordasiewicz H, Watt AT, Freier SM, Hung G, Seth PP, Bennett CF, Swayze EE, Hayden MR. Skotte NH, et al. Among authors: warby sc. PLoS One. 2014 Sep 10;9(9):e107434. doi: 10.1371/journal.pone.0107434. eCollection 2014. PLoS One. 2014. PMID: 25207939 Free PMC article.

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