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Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.
Amin DN, Bielenberg DR, Lifshits E, Heymach JV, Klagsbrun M. Amin DN, et al. Among authors: klagsbrun m. Microvasc Res. 2008 May;76(1):15-22. doi: 10.1016/j.mvr.2008.01.002. Epub 2008 Mar 18. Microvasc Res. 2008. PMID: 18440031
We have previously reported that EGFR is not only expressed by the tumor cells but by the tumor endothelial cells (EC) as well (Amin, D. N., Hida, K., Bielenberg, D. R., Klagsbrun, M., 2006. Tumor endothelial cells express epidermal growth factor receptor (EGFR) but …
We have previously reported that EGFR is not only expressed by the tumor cells but by the tumor endothelial cells (EC) as well (Amin, D. N., …
Neuropilins in neoplasms: expression, regulation, and function.
Bielenberg DR, Pettaway CA, Takashima S, Klagsbrun M. Bielenberg DR, et al. Among authors: klagsbrun m. Exp Cell Res. 2006 Mar 10;312(5):584-93. doi: 10.1016/j.yexcr.2005.11.024. Epub 2006 Jan 27. Exp Cell Res. 2006. PMID: 16445911 Review.
Targeting endothelial and tumor cells with semaphorins.
Bielenberg DR, Klagsbrun M. Bielenberg DR, et al. Among authors: klagsbrun m. Cancer Metastasis Rev. 2007 Dec;26(3-4):421-31. doi: 10.1007/s10555-007-9097-4. Cancer Metastasis Rev. 2007. PMID: 17768598 Review.
Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M. Shimizu A, et al. Among authors: klagsbrun m. J Biol Chem. 2013 Jan 25;288(4):2210-22. doi: 10.1074/jbc.M112.397398. Epub 2012 Nov 29. J Biol Chem. 2013. PMID: 23195957 Free PMC article.
270 results