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Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
McCubrey JA, Sokolosky ML, Lehmann BD, Taylor JR, Navolanic PM, Chappell WH, Abrams SL, Stadelman KM, Wong EW, Misaghian N, Horn S, Bäsecke J, Libra M, Stivala F, Ligresti G, Tafuri A, Milella M, Zarzycki M, Dzugaj A, Chiarini F, Evangelisti C, Martelli AM, Terrian DM, Franklin RA, Steelman LS. McCubrey JA, et al. Among authors: dzugaj a. Adv Enzyme Regul. 2008;48:113-35. doi: 10.1016/j.advenzreg.2008.02.006. Epub 2008 Feb 21. Adv Enzyme Regul. 2008. PMID: 18423407 Free PMC article.
Rabbit muscle fructose-1,6-bisphosphatase is phosphorylatedin vivo.
Rakus D, Zarzycki M, Dzugaj A. Rakus D, et al. Among authors: dzugaj a. Acta Biochim Pol. 2003;50(1):115-21. Acta Biochim Pol. 2003. PMID: 12673351
The phosphorylated FBPase (P-FBPase) differs from the dephosphorylated enzyme in terms of its kinetic properties like K(m) and k(cat), which are two times higher for the phosphorylated FBPase, and in the affinity for aldolase, which is three times lower for the dephosphorylated e …
The phosphorylated FBPase (P-FBPase) differs from the dephosphorylated enzyme in terms of its kinetic properties like K(m) and k(cat), which …
Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase.
Zarzycki M, Kołodziejczyk R, Maciaszczyk-Dziubinska E, Wysocki R, Jaskolski M, Dzugaj A. Zarzycki M, et al. Among authors: dzugaj a. Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1028-34. doi: 10.1107/S090744491104385X. Epub 2011 Nov 18. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 22120740
Structural studies of human muscle FBPase.
Barciszewski J, Szpotkowski K, Wisniewski J, Kolodziejczyk R, Rakus D, Jaskolski M, Dzugaj A. Barciszewski J, et al. Among authors: dzugaj a. Acta Biochim Pol. 2021 Jan 27;68(1):5-14. doi: 10.18388/abp.2020_5554. Acta Biochim Pol. 2021. PMID: 33502838 Free article.
52 results