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Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals.
Maeda H, Kodaira H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Maeda H, et al. Among authors: fujita k. Xenobiotica. 2012 Jul;42(7):649-59. doi: 10.3109/00498254.2011.652993. Epub 2012 Feb 10. Xenobiotica. 2012. PMID: 22324379
Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: a pharmacokinetic study in male and female rats.
Maeda H, Fujita K, Kobayashi H, Ushiki J, Nakanishi T, Tamai I. Maeda H, et al. Among authors: fujita k. Arzneimittelforschung. 2012 May;62(5):213-21. doi: 10.1055/s-0032-1301883. Epub 2012 Feb 16. Arzneimittelforschung. 2012. PMID: 22344572
An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW-2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins.
Hosogi J, Ohashi R, Maeda H, Fujita K, Ushiki J, Kuwabara T, Yamamoto Y, Imamura T. Hosogi J, et al. Among authors: fujita k. Biopharm Drug Dispos. 2018 Mar;39(3):164-174. doi: 10.1002/bdd.2123. Biopharm Drug Dispos. 2018. PMID: 29451686
Dementia Care Research and Psychosocial Factors.
Fujita K, Sugimoto T, Matsumoto N, Uchida K, Kuroda Y, Arai H, Sakurai T; J‐MINT study group. Fujita K, et al. Alzheimers Dement. 2024 Dec;20 Suppl 4:e086076. doi: 10.1002/alz.086076. Alzheimers Dement. 2024. PMID: 39782458
Dementia Care Research and Psychosocial Factors.
Uchida K, Sugimoto T, Jin X, Nakagawa T, Ogata S, Kiyoshige E, Fujita K, Kuroda Y, Sakurai T, Saito T. Uchida K, et al. Among authors: fujita k. Alzheimers Dement. 2024 Dec;20 Suppl 4:e088462. doi: 10.1002/alz.088462. Alzheimers Dement. 2024. PMID: 39782125
5,223 results