Workman P - Search Results

1

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, Patterson L, de Haven Brandon A, Gowan S, Boxall F, Aherne W, Rowlands M, Hayes A, Martins V, Urban F, Boxall K, Prodromou C, Pearl L, James K, Matthews TP, Cheung KM, Kalusa A, Jones K, McDonald E, Barril X, Brough PA, Cansfield JE, Dymock B, Drysdale MJ, Finch H, Howes R, Hubbard RE, Surgenor A, Webb P, Wood M, Wright L, Workman P. Eccles SA, et al. Among authors: workman p. Cancer Res. 2008 Apr 15;68(8):2850-60. doi: 10.1158/0008-5472.CAN-07-5256. Cancer Res. 2008. PMID: 18413753

2

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.

Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P. Kelland LR, et al. Among authors: workman p. J Natl Cancer Inst. 1999 Nov 17;91(22):1940-9. doi: 10.1093/jnci/91.22.1940. J Natl Cancer Inst. 1999. PMID: 10564678

3

Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Sharp SY, et al. Among authors: workman p. Mol Pharmacol. 2000 Nov;58(5):1146-55. doi: 10.1124/mol.58.5.1146. Mol Pharmacol. 2000. PMID: 11040064

4

Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Hostein I, et al. Among authors: workman p. Cancer Res. 2001 May 15;61(10):4003-9. Cancer Res. 2001. PMID: 11358818

5

Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.

Smith V, Raynaud F, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Mol Pharmacol. 2001 Nov;60(5):885-93. doi: 10.1124/mol.60.5.885. Mol Pharmacol. 2001. PMID: 11641415

6

High-throughput screening for identification of small molecule inhibitors of histone acetyltransferases using scintillating microplates (FlashPlate).

Turlais F, Hardcastle A, Rowlands M, Newbatt Y, Bannister A, Kouzarides T, Workman P, Aherne GW. Turlais F, et al. Among authors: workman p. Anal Biochem. 2001 Nov 1;298(1):62-8. doi: 10.1006/abio.2001.5340. Anal Biochem. 2001. PMID: 11673896

7

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR. Kelland LR, et al. Among authors: workman p. Clin Cancer Res. 2001 Nov;7(11):3544-50. Clin Cancer Res. 2001. PMID: 11705875

8

HSP90 as a new therapeutic target for cancer therapy: the story unfolds.

Maloney A, Workman P. Maloney A, et al. Among authors: workman p. Expert Opin Biol Ther. 2002 Jan;2(1):3-24. doi: 10.1517/14712598.2.1.3. Expert Opin Biol Ther. 2002. PMID: 11772336 Review.

9

Assays for the identification and evaluation of histone acetyltransferase inhibitors.

Wynne Aherne G, Rowlands MG, Stimson L, Workman P. Wynne Aherne G, et al. Among authors: workman p. Methods. 2002 Mar;26(3):245-53. doi: 10.1016/S1046-2023(02)00028-2. Methods. 2002. PMID: 12054880

10

Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.

Smith V, Rowlands MG, Barrie E, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Clin Cancer Res. 2002 Jun;8(6):2002-9. Clin Cancer Res. 2002. PMID: 12060646

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