Wouters J - Search Results

1

Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes.

de Ruyck J, Wouters J. de Ruyck J, et al. Among authors: wouters j. Curr Protein Pept Sci. 2008 Apr;9(2):117-137. doi: 10.2174/138920308783955261. Curr Protein Pept Sci. 2008. PMID: 18393884 Review.

2

Structure of Thermus thermophilus type 2 isopentenyl diphosphate isomerase inferred from crystallography and molecular dynamics.

de Ruyck J, Rothman SC, Poulter CD, Wouters J. de Ruyck J, et al. Among authors: wouters j. Biochem Biophys Res Commun. 2005 Dec 23;338(3):1515-8. doi: 10.1016/j.bbrc.2005.10.114. Epub 2005 Oct 27. Biochem Biophys Res Commun. 2005. PMID: 16269131

3

3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa.

Frédérick R, Robert S, Charlier C, de Ruyck J, Wouters J, Pirotte B, Masereel B, Pochet L. Frédérick R, et al. Among authors: wouters j. J Med Chem. 2005 Dec 1;48(24):7592-603. doi: 10.1021/jm050448g. J Med Chem. 2005. PMID: 16302799

4

Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.

de Ruyck J, Durisotti V, Oudjama Y, Wouters J. de Ruyck J, et al. Among authors: wouters j. J Biol Chem. 2006 Jun 30;281(26):17864-9. doi: 10.1074/jbc.M601851200. Epub 2006 Apr 15. J Biol Chem. 2006. PMID: 16617181 Free article.

5

Overexpression, physicochemical characterization, and modeling of a hyperthermophilic pyrococcus furiosus type 2 IPP isomerase.

Dutoit R, de Ruyck J, Durisotti V, Legrain C, Jacobs E, Wouters J. Dutoit R, et al. Among authors: wouters j. Proteins. 2008 Jun;71(4):1699-707. doi: 10.1002/prot.21863. Proteins. 2008. PMID: 18076031

6

Monoclinic form of isopentenyl diphosphate isomerase: a case of polymorphism in biomolecular crystals.

de Ruyck J, Oudjama Y, Wouters J. de Ruyck J, et al. Among authors: wouters j. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt 4):239-42. doi: 10.1107/S174430910800568X. Epub 2008 Mar 21. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18391416 Free PMC article.

7

Crystal structure of type 2 isopentenyl diphosphate isomerase from Thermus thermophilus in complex with inorganic pyrophosphate.

de Ruyck J, Pouyez J, Rothman SC, Poulter D, Wouters J. de Ruyck J, et al. Among authors: wouters j. Biochemistry. 2008 Sep 2;47(35):9051-3. doi: 10.1021/bi801159x. Epub 2008 Aug 12. Biochemistry. 2008. PMID: 18693754 Free PMC article.

8

Analysis of the interactions taking place in the recognition site of a bimetallic Mg(II)-Zn(II) enzyme, isopentenyl diphosphate isomerase. a parallel quantum-chemical and polarizable molecular mechanics study.

Gresh N, Audiffren N, Piquemal JP, de Ruyck J, Ledecq M, Wouters J. Gresh N, et al. Among authors: wouters j. J Phys Chem B. 2010 Apr 15;114(14):4884-95. doi: 10.1021/jp907629k. J Phys Chem B. 2010. PMID: 20329783

9

Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes.

de Ruyck J, Wouters J, Poulter CD. de Ruyck J, et al. Among authors: wouters j. Curr Enzym Inhib. 2011 Jul;7(2):10.2174/157340811796575317. doi: 10.2174/157340811796575317. Curr Enzym Inhib. 2011. PMID: 24339799 Free PMC article.

10

Determination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase from Streptococcus pneumoniae.

de Ruyck J, Janczak MW, Neti SS, Rothman SC, Schubert HL, Cornish RM, Matagne A, Wouters J, Poulter CD. de Ruyck J, et al. Among authors: wouters j. Chembiochem. 2014 Jul 7;15(10):1452-8. doi: 10.1002/cbic.201402046. Epub 2014 Jun 6. Chembiochem. 2014. PMID: 24910111 Free PMC article.

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